Clinical and pathologic factors associated with survival in young adult patients with fibrolamellar hepatocarcinomaReport as inadecuate

Clinical and pathologic factors associated with survival in young adult patients with fibrolamellar hepatocarcinoma - Download this document for free, or read online. Document in PDF available to download.

BMC Cancer

, 5:142

First Online: 31 October 2005Received: 25 April 2005Accepted: 31 October 2005DOI: 10.1186-1471-2407-5-142

Cite this article as: Moreno-Luna, L.E., Arrieta, O., García-Leiva, J. et al. BMC Cancer 2005 5: 142. doi:10.1186-1471-2407-5-142


BackgroundFibrolamellar Carcinoma FLC, a subtype of hepatocellular carcinoma HCC, is a rare primary hepatic malignancy. Several aspects of the clinic features and epidemiology of FLC remain unclear because most of the literature on FLC consists of case reports and small cases series with limited information on factors that affect survival.

MethodsWe did a retrospective analysis of the clinical and histological characteristics of FLC. We also determined the rate of cellular proliferation in biopsies of these tumors. We assessed whether these variables were associated with survival.

ResultsWe found 15 patients with FLC out of 174 patients with HCC 8.6%. Between patients with these neoplasms, we found statistically significant survival, age at onset, level of alpha fetoprotein, and an earlier stage of the disease. The 1, 3 and 5 year survival in patients with FLC was of 66, 40 and 26% respectively. The factors associated with a higher survival in patients with FLC were age more than 23 years, feasibility of surgical resection, free surgical borders, absence of thrombosis or invasion to hepatic vessels and the absence of alterations in liver enzymes. The size of the tumor, gender, cellular proliferation and atypia did not affect the prognosis.

ConclusionWe concluded that FLC patients diagnosed before 23 years of age have worse prognosis than those diagnosed after age 23. Other factors associated with worse prognosis in this study are: lack of surgical treatment, presence of positive surgical margins, vascular invasion, and altered hepatic enzymes.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-5-142 contains supplementary material, which is available to authorized users.

Laura E Moreno-Luna, Jorge García-Leiva, Braulio Martínez, Aldo Torre, Misael Uribe and Eucario León-Rodríguez contributed equally to this work.

Download fulltext PDF

Author: Laura E Moreno-Luna - Oscar Arrieta - Jorge García-Leiva - Braulio Martínez - Aldo Torre - Misael Uribe - Eucario León-


Related documents