Viral load responses to HAART is an independent predictor of a new AIDS event in late stage HIV infected patients: prospective cohort studyReport as inadecuate




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Journal of Translational Medicine

, 3:40

First Online: 31 October 2005Received: 12 July 2005Accepted: 31 October 2005DOI: 10.1186-1479-5876-3-40

Cite this article as: Kazanjian, P., Wei, W., Brown, M. et al. J Transl Med 2005 3: 40. doi:10.1186-1479-5876-3-40

Abstract

BackgroundA sizeable number of HIV-infected patients receiving HAART do not maintain prolonged virologic suppression. We evaluated long-term HIV viral load VL responses to HAART as a risk factor for AIDS events AE that is independent of CD4 responses.

MethodsA cohort of patients with pre-therapy CD4 < 200-mm who had CD4 and VL measurements for > one year after receiving HAART at a university clinic were prospectively enrolled. Cox proportional multivariate regression model was used to determine whether CD4 and VL responses were independently associated with new AE.

ResultsThe patient N = 214 mean baseline CD4 = 92-mm, VL = 219,000 c-mL and follow-up duration 42.3 months range 13–72 months. A new AE occurred in 56 patients; CD4 cell count response to HAART that remained < 200-mm throughout the study period was a significant risk factor for new AE RR = 9.7–12.5; p < 0.001. Similarly, VL responses that remained > 5,000 c-mL during this period was also a significant risk factor RR = 6.7–12.8; p = 0.001 that was independent of CD4 response adjusted for <> 200-mm.

ConclusionMaintaining adequate long-term virologic responses to HAART provides a clinical benefit independent of CD4 responses.

KeywordsViral Load CD4 HAART AIDS Electronic supplementary materialThe online version of this article doi:10.1186-1479-5876-3-40 contains supplementary material, which is available to authorized users.

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Author: Powel Kazanjian - Wei Wei - Morton Brown - Tejal Gandhi - Kamal Amin

Source: https://link.springer.com/







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