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Severe Acute Respiratory SSARS, coronavirus, genome, phylogeny

Additional contributors:

Subject-Keyword: Severe Acute Respiratory SSARS coronavirus genome phylogeny

Type of item: Journal Article Published

Language: English




Date created: 2003-05-01

DOI: doi:10.7939-R3CV4BV74

License information:

Rights: © 2015 Springer unless otherwise stated. Part of Springer Science+Business Media.

Author: Severe Acute Respiratory SARS coronavirus genome phylogeny

Source: https://era.library.ualberta.ca/


Chinese Science Bulletin 2003 Vol.
48 No.1 0 941-948 A complete sequence and comparative analysis of a SARS-associated virus (Isolate BJOl) QIN Ede, ZHU Qingyu*, YU Man, FAN Baochang, CHANG Guohui, SI Bingyin, YANG Baoan, PENG Wenming, JIANG Tao, L1U Bohua, DENG Yongqiang, L1U Hong, ZHANG Yu, WANG Cuie, LI Yuquan, GAN Yonghua, LI Xiaoyu, LO Fushuang, TAN Gang, CAO Wuchun, YANG Ruifu mutations) in the proteins.
Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to be involved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the M protein, which could be related to viral envelope formation.
Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides no evidence that they are man-made.
Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of other possible SARS-related pathogen(s). Keywords: Severe Acute Respiratory Syndrome (SARS), coronavirus, genome, phylogeny. DOl: lO.1360-03wc0186 Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300; National Center for Genome Information, Beijing 101300, China * Correspondence should be addressed to Zhu Qingyu (e-mail: zhuqy@ nic.bmi.ac.cn) and Yang Huanming (e-mail: yanghm@genomics.org.cn) Severe Acute Respiratory Syndrome (SARS) is a newly identified infectious disease[l-51.
The global outbreak of SARS has been threatening the health of people worldwide and has killed 353 people and infected more than 5462 in 27 countries, as reported by WHO on April 29, 2003 (http:--www.who.int-csr-sarscountry-en).Although it has been recognized that a variant of virus from the family of coronavirus might be the candidate pathogen of SARS[I-51, its identity as the unique pathogen still remains controversial (http:--www.nytimes.com-2003-04- 24-science-24INF...

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