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Gastroenterology Research and Practice - Volume 2017 2017, Article ID 4148651, 6 pages - https:-doi.org-10.1155-2017-4148651

Research Article

Qilu Hospital, Shandong University, Ji’nan, Shandong 250012, China

Department of Gastroenterology, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, China

Correspondence should be addressed to Ming Lv

Received 24 October 2016; Accepted 14 December 2016; Published 12 January 2017

Academic Editor: Paolo Gionchetti

Copyright © 2017 Hao Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aims. Fucosyltransferase 2 FUT2 gene potentially affects the constituent of intestinal microbiota, which play a crucial role in the pathogenesis of inflammatory bowel disease IBD. This study investigated the association of FUT2 gene polymorphisms with IBD in southeast China. Methods. We collected 671 IBD patients and 502 healthy controls. FUT2 gene polymorphisms C357T, A385T, and G428A were determined by SNaPshot. Frequencies of the FUT2 genotypes, alleles, and haplotype between groups were compared by test. Results. The allele and genotype frequencies of FUT2 did not differ between ulcerative colitis patients and controls all . However, mutant allele and genotype of FUT2 A385T were significantly increased in Crohn’s disease CD patients , OR = 1.271, and 95% CI = 1.031–1.565; , OR = 1.927, and 95% CI = 1.353–2.747, resp

The same conclusion was drawn from FUT2 G428A , OR = 3.324, and 95% CI = 1.108–9.968; , OR = 1.116–10.137, and 95% CI = 1.116–10.137, resp

The haplotype TT formed with -C357T and A385T- was more prevalent in CD patients than in controls , OR = 1.277, and 95% CI = 1.036–1.573. Besides, frequencies of mutant allele and genotype of FUT2 A385T were significantly lower in patients with ileocolonic CD than in those with colonic CD and 0.002, resp. and ileal CD and 0.004, resp

Conclusions. FUT2 gene polymorphisms and haplotypes were associated with the susceptibility to CD but not UC.





Autor: Hao Wu, Liang Sun, Dao-po Lin, Xiao-xiao Shao, Sheng-long Xia, and Ming Lv

Fuente: https://www.hindawi.com/



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