A PROgramme of Lifestyle Intervention in Families for Cardiovascular risk reduction PROLIFIC Study: design and rationale of a family based randomized controlled trial in individuals with family history of premature coronary heart Reportar como inadecuado




A PROgramme of Lifestyle Intervention in Families for Cardiovascular risk reduction PROLIFIC Study: design and rationale of a family based randomized controlled trial in individuals with family history of premature coronary heart - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Public Health

, 17:10

Chronic Disease epidemiology

Abstract

BackgroundRecognizing patterns of coronary heart disease CHD risk in families helps to identify and target individuals who may have the most to gain from preventive interventions. The overall goal of the study is to test the effectiveness and sustainability of an integrated care model for managing cardiovascular risk in high risk families. The proposed care model targets the structural and environmental conditions that predispose high risk families to development of CHD through the following interventions: 1 screening for cardiovascular risk factors, 2 providing lifestyle interventions 3 providing a framework for linkage to appropriate primary health care facility, and 4 active follow-up of intervention adherence.

MethodsInitially, a formative qualitative research component will gather information on understanding of diseases, barriers to care, specific components of the intervention package and feedback on the intervention. Then a cluster randomized controlled trial involving 740 families comprising 1480 participants will be conducted to determine whether the package of interventions integrated care model is effective in reducing or preventing the progression of CHD risk factors and risk factor clustering in families. The sustainability and scalability of this intervention will be assessed through economic cost-effectiveness analyses and qualitative evaluation process outcomes to estimate value and acceptability. Scalability is informed by cost-effectiveness and acceptability of the integrated cardiovascular risk reduction approach.

DiscussionKnowledge generated from this trial has the potential to significantly affect new programmatic policy and clinical guidelines that will lead to improvements in cardiovascular health in India.

Trial registration numberNCT02771873, registered in May 2016 https:-clinicaltrials.gov-ct2-show-results-NCT02771873

AbbreviationsAIIMSAll India Institute of Medical Sciences

BMIBody Mass Index

BPBlood pressure

CHDCoronary heart disease

CVDCardiovascular disease

DBPDiastolic blood pressure

EQASExternal quality assurance programs

FCHWFrontline community health workers

FFQFood frequency questionnaire

FGDsFocus group discussions

FH+Positive family history

FPGFasting blood glucose

GDPGross domestic product

GEEGeneralised estimating equations

HbA1cHeamoglobin A1c

ICCIntra-class correlation coefficient

LDLLow density lipoprotein

NABLNational Accreditation Board for testing and calibration of Laboratories

PHFIPublic Health Foundation of India

QALYQuality adjusted life years

RCTRandomized controlled trial

SBPSystolic blood pressure

SCTIMSTSree Chitra Tirunal Instutute for Medical Sciences and Technology

TCTotal cholesterol

WHOWorld Health Organization

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Autor: Panniyammakal Jeemon - S. Harikrishnan - G. Sanjay - Sivasankaran Sivasubramonian - T. R. Lekha - Sandosh Padmanabhan - Nik

Fuente: https://link.springer.com/







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