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BMC Research Notes

, 10:42

Health services research


BackgroundIn the US, approximately 12.7% of all live births are preterm, 8.2% of live births were low birth weight LBW, and 1.5% are very low birth weight VLBW. Although technological advances have improved mortality rates among preterm and LBW infants, improving overall rates of prematurity and LBW remains a national priority. Monitoring short- and long-term outcomes is critical for advancing medical treatment and minimizing morbidities associated with prematurity or LBW; however, studying these infants can be challenging. Several large, multi-center neonatal databases have been developed to improve research and quality improvement of treatments for and outcomes of premature and LBW infants. The purpose of this systematic review was to describe three multi-center neonatal databases.

MethodsWe conducted a literature search using PubMed and Google Scholar over the period 1990 to August 2014. Studies were included in our review if one of the databases was used as a primary source of data or comparison. Included studies were categorized by year of publication; study design employed, and research focus.

ResultsA total of 343 studies published between 1991 and 2014 were included. Studies of premature and LBW infants using these databases have increased over time, and provide evidence for both neonatology and community-based pediatric practice.

ConclusionsResearch into treatment and outcomes of premature and LBW infants is expanding, partially due to the availability of large, multicenter databases. The consistency of clinical conditions and neonatal outcomes studied since 1990 demonstrates that there are dedicated research agendas and resources that allow for long-term, and potentially replicable, studies within this population.

KeywordsNICU outcomes Pediatrics outcomes NICU databases Prematurity AbbreviationsLBWlow birth weight

VLBWvery low birth weight

ELBWextremely low birth weight

NICUneonatal intensive care unit

KPNMDSKaiser permanente neonatal minimum data set

VONVermont Oxford Network

NICHD NRNEunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

NPICNational Perinatal Information Center

NECnecrotizing enterocolitis

Electronic supplementary materialThe online version of this article doi:10.1186-s13104-016-2336-4 contains supplementary material, which is available to authorized users.

Autor: Liza M. Creel - Sean Gregory - Catherine J. McNeal - Madhava R. Beeram - David R. Krauss


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