Seroprevalence of Toxoplasma gondii and associated risk factors among HIV-infected women within reproductive age group at Mizan Aman General Hospital, Southwest Ethiopia: a cross sectional studyReportar como inadecuado




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BMC Research Notes

, 10:70

First Online: 26 January 2017Received: 09 October 2015Accepted: 17 January 2017DOI: 10.1186-s13104-017-2390-6

Cite this article as: Zeleke, A.J. & Melsew, Y.A. BMC Res Notes 2017 10: 70. doi:10.1186-s13104-017-2390-6

Abstract

BackgroundToxoplasmosis is serious in the case of immune suppression and prenatal transmission. In immunocompromised hosts, it is manifested primarily as a life-threatening condition, toxoplasmic encephalitis. Congenital toxoplasmosis results in abortion or congenitally acquired disorders which primarily affect the central nervous system. This study assessed seroprevalence of Toxoplasma gondii T. gondii infection and associated factors among HIV-infected women within the reproductive age group 18–49 years at Mizan Aman General Hospital, Southwest Ethiopia. An institution based cross-sectional study was conducted from February 01 to May 30, 2015. Systematic random sampling technique was employed for participant selection. Enzyme linked immuno sorbent assay was used to test for T. gondii from venous blood specimens. Participants were interviewed using structured questionnaire for different variables. Descriptive statistics, binary and multivariable logistic regression analyses were performed during data analysis. P value of less than 0.05 was considered statistically significant.

ResultsA total of 270 HIV-infected women within the reproductive age group were included in the study. Mean age of the respondents was 31 years SD = ±6.5. Of the total study participants, 255 94.4%, 95% CI 91.6, 97.2% were found to be seropositive for T. gondii anti-immunoglobulin G IgG antibody, and 6 2.2%, 95% CI 1.3, 3.1% for anti-immunoglobulin M IgM. All the anti-IgM positive samples were also positive for IgG. Multivariate analysis showed that; age within 28–37 years Adjusted Odds Ratio AOR 2.58, 95% CI 1.01, 6.60, level of education with unable or only able to read and write AOR = 4.46, 95% CI 1.20, 16.60, and substance abuse AOR = 4.49, 95 CI 1.60, 12.55 were significantly associated with seropositivity of T. gondii infection.

ConclusionsSeroprevalence of toxoplasmosis among the HIV-infected women in the childbearing age group in Mizan Aman was high. Age, educational status and drug addiction were identified as factors associated with T. gondii infection. Education of HIV-infected women about the transmission and prevention methods of T. gondii infection is important. Besides, studies on incidence of toxoplasmosis in newborns and infants are recommended.

KeywordsSeroprevalence Toxoplasma gondii HIV-infected women Ethiopia AbbreviationsAIDSacquired immune deficiency syndrome

AORadjusted odds ratio

ARTantiretroviral treatment

CORcrude odds ratio

ELISAenzyme linked immune sorbent assay

HAARThighly active antiretroviral therapy

HIVhuman immuno deficiency virus

IgGimmunoglobulin G

IgMimmunoglobulin M

TEtoxoplasmic encephalitis





Autor: Ayalew Jejaw Zeleke - Yayehirad Alemu Melsew

Fuente: https://link.springer.com/







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