Effects of 5-Amyno-4-1,3-benzothyazol-2-yn-1-3-methoxyphenyl-1,2-dihydro-3H-pyrrol-3-one Intake on Digestive System in a Rat Model of Colon CancerReportar como inadecuado




Effects of 5-Amyno-4-1,3-benzothyazol-2-yn-1-3-methoxyphenyl-1,2-dihydro-3H-pyrrol-3-one Intake on Digestive System in a Rat Model of Colon Cancer - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

The Scientific World Journal - Volume 2015 2015, Article ID 376576, 13 pages -

Research ArticleInstitute of Biology, Taras Shevchenko National University, 64-13 Volodymyrska Street, Kyiv 01601, Ukraine

Received 29 April 2015; Revised 2 September 2015; Accepted 9 September 2015

Academic Editor: Péter Krajcsi

Copyright © 2015 Halyna M. Kuznietsova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. Pyrrol derivate 5-amyno-4-1,3-benzothyazol-2-yn-1-3-methoxyphenyl-1,2-dihydro-3H-pyrrol-3-one D1 has shown antiproliferative activities in vitro, so investigation of the impact of D1 intake on gut organs in rats that experienced colon cancer seems to be necessary. Materials and Methods. D1 at the dose of 2.3 mg-kg was administered per os daily for 27 from the 1st day of experiment or 7 from the 21st week of experiment weeks to rats that experienced 1,2-dimethylhydrazine DMH-induced colon cancer for 20 weeks. 5-Fluorouracil 5FU was chosen as reference drug and was administered intraperitoneally weekly for 7 weeks from the 21st week of experiment at the dose of 45 mg-kg. Results. Antitumor activity of D1 comparable with the 5FU one against DMH-induced colon cancer in rats was observed decrease of tumor number and tumor total area up to 46%. D1 attenuated the inflammation of colon, gastric and jejunal mucosa, and the liver, caused by DMH, unlike 5FU, aggravating the latter. In addition, D1 partially normalized mucosa morphometric parameters suggesting its functional restore. Conclusions. D1 possesses, comparable with 5-fluorouracil antitumor efficacy, less damaging effects on the tissues beyond cancerous areas and contributes to partial morphological and functional gut organs recovery.





Autor: Halyna M. Kuznietsova, Valentyna K. Luzhenetska, Iryna P. Kotlyar, and Volodymyr K. Rybalchenko

Fuente: https://www.hindawi.com/



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