Granzyme B; the chalk-mark of a cytotoxic lymphocyteReportar como inadecuado

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Journal of Translational Medicine

, 2:36

First Online: 25 October 2004Received: 27 September 2004Accepted: 25 October 2004DOI: 10.1186-1479-5876-2-36

Cite this article as: Waterhouse, N.J., Sedelies, K.A. & Clarke, C.J. J Transl Med 2004 2: 36. doi:10.1186-1479-5876-2-36


During cytotoxic lymphocyte CL mediated killing of target cells, granzyme B is released from the CL into the immune synapse. Recent studies have found that ELISPOT-detection of granzyme B correlated well with conventional assays for CL mediated killing. In this way, the released granzyme B can be used to mark the spot where a target cell was murdered. We discuss the benefits and potential limitations of using this assay to measure CL mediated killing of target cells.

AbbreviationsCLcytotoxic lymphocytes

ELISPOTenzyme linked immunospot


Autor: Nigel J Waterhouse - Karin A Sedelies - Chris JP Clarke


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