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Gastroenterology Research and PracticeVolume 2012 2012, Article ID 343812, 6 pages

Research Article

Division of Gastroenterology and Hepatology, School of Medicine, University of North Carolina at Chapel Hill, Bioinformatics Building, Suite 4143, 130 Mason Farm Road, Chapel Hill, NC 27599-7080, USA

School of Medicine, Universidad Nacional Autónoma de Nicaragua UNAN, León, Nicaragua

School of Medicine, Universidad Nacional Autónoma de México UNAM, Hospital General de México, Mexico City, DF, Mexico

Centro de Intervención e Intervenciones en Salud, León, Nicaragua

Received 26 October 2011; Accepted 7 December 2011

Academic Editor: Magnus Simren

Copyright © 2012 Douglas R. Morgan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Postinfectious IBS is defined in the industrialized world as IBS onset following a sentinel gastrointestinal infection. In developing nations, where repeated bacterial and parasitic gastrointestinal infections are common, the IBS pathophysiology may be altered. Our aim was to investigate the relationship between intestinal parasite infection and IBS in the “nonsterile” developing world environment. IBS subjects were identified from a population-based sample of 1624 participants using the Rome II Modular Questionnaire. Stool samples from cases and randomly selected controls were examined for ova and parasites. Logistic regression models explored the relationship between IBS and parasite infection. The overall IBS prevalence among participants was 13.2% 9.3% males, 15.9% females. There was no difference in parasite carriage between IBS cases and controls, 16.6% versus 15.4% , nor among IBS subtypes. The pathophysiology of post-infectious IBS may be altered in the developing world as compared to industrialized nations and warrants investigation.

Autor: Douglas R. Morgan, Matthew Benshoff, Mercedes Cáceres, Sylvia Becker-Dreps, Loreto Cortes, Christopher F. Martin, Max Schmu



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