A randomized, placebo-controlled trial of prednisone in early Henoch Schönlein Purpura ISRCTN85109383Reportar como inadecuado




A randomized, placebo-controlled trial of prednisone in early Henoch Schönlein Purpura ISRCTN85109383 - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Medicine

, 2:7

First Online: 02 April 2004Received: 03 February 2004Accepted: 02 April 2004DOI: 10.1186-1741-7015-2-7

Cite this article as: Huber, A.M., King, J., McLaine, P. et al. BMC Med 2004 2: 7. doi:10.1186-1741-7015-2-7

Abstract

BackgroundHenoch Schönlein Purpura HSP is the most common systemic vasculitis of childhood. There is considerable controversy over whether children with HSP should be treated with corticosteroids. The goal of this study was to investigate whether early corticosteroid administration could reduce the rate of renal or gastrointestinal complications in children with HSP.

MethodsForty children with HSP, seen in the emergency room of a tertiary-care, paediatric centre, entered a randomized, double-blind, placebo controlled study. The treatment group n = 21 received oral prednisone, 2 mg-kg-day for one week, with weaning over a second week, while the placebo group n = 19 received an identical appearing placebo. Co-primary outcomes were the rate of renal involvement at one year and the rate of acute gastrointestinal complications. Co-primary outcomes were analysed using Fisher-s Exact test.

ResultsAt one year, there was no difference in the rate of renal involvement 3-21 prednisone group vs. 2-19 placebo group, P = 1.0. There was also no statistically significant difference in the rate of acute gastrointestinal complications 2-21 prednisone group vs. 3-19 placebo group, P = 0.7. Two children in the placebo group did experience intussusceptions compared with none in the prednisone group P = 0.2.

ConclusionsEarly prednisone therapy in HSP does not appear to reduce the risk of renal involvement at one year, or the risk of acute gastrointestinal complications. There may be a reduced risk of intussusception. The routine, early use of prednisone in uncomplicated HSP cannot be recommended at this time.

Electronic supplementary materialThe online version of this article doi:10.1186-1741-7015-2-7 contains supplementary material, which is available to authorized users.





Autor: Adam M Huber - Jim King - Peter McLaine - Terry Klassen - Mary Pothos

Fuente: https://link.springer.com/







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