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BMC Research Notes

, 9:459

Cardiovascular Disorders


BackgroundIn patients with cardiomyopathy of unknown origin, endomyocardial biopsy provides the possibility of improved diagnosis and tailored treatment. Specific guidance has been developed based on cardiovascular centre of excellence experience but it is unknown if the benefits also extend into the tertiary care hospital setting.

MethodsEndomyocardial biopsies was performed in patients with cardiomyopathy of unknown origin. The outcomes were mirrored against the current ESC recommendations.

ResultsA total of 57 patients with cardiomyopathy of unknown origin underwent endomyocardial biopsy with a mean age of 54 years and 28 % being women. In 17 patients 30 %, viruses were detected in the biopsy material, in 6 patients 11 % cardiac amyloidosis was found of which 3 had also a positive test for viruses. The overall mortality rate was 18 % in the mean follow up period of 30 months, with a rate of 24 % in those with virus detection mean FU 24 months and 15 % in those without virus detection mean FU 31 months. Death rates were 83 % in patients with cardiac amyloidosis mean FU 10 months.

ConclusionWe conclude that, limited by uncertainty stemming from the small number of included patients, endomyocardial biopsy may not prove to have a clinical impact on treatment decisions and outcomes in a tertiary care hospital setting. We consider cardiac amyloidosis to be an exception, since the mortality rate with or without concomitant virus load was extremely high.

KeywordsCardiomyopathy Myocardial biopsy Myocarditis Cardiac amyloidosis Viral AbbreviationsACCAmerican College of Cardiology

AHAAmerican Heart Association

ARVD-Carrhythmogenic right ventricular dysplasia- cardiomyopathy

ATTRtransthyretin- related amyloidosis

DCMdilated cardiomyopathy

EFejection fraction

ESCEuropean Society of Cardiology

HCMhypertrophic cardiomyopathy

HEhaematoxylin- eosin

MRImagnetic resonance imaging

PCRpolymerase chain reaction

RT- PCRreverse transcription PCR

SSAsystemic senile amyloidosis


TTR-FAPtransthyretin familial amyloid polyneuropathy

Autor: Ulrich Tebbe - Karin Bramlage - Fiete John - Dirk Härtel - Ralf Felgendreher - Kathrin Machalke - Reinhard Kandolf - Peter

Fuente: https://link.springer.com/

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