Studies on Early Allergic Sensitization in the Lithuanian Birth CohortReport as inadecuate

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The Scientific World Journal - Volume 2012 2012, Article ID 909524, 6 pages -

Research Article

Vilnius University Faculty of Medicine, University Street 3 01513, Vilnius, Lithuania

Institute of Biotechnology of Vilnius University, Graiciuno Street 8 02241, Vilnius, Lithuania

Received 31 October 2011; Accepted 4 December 2011

Academic Editor: Gerard Guillet

Copyright © 2012 Ruta Dubakiene et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cohort studies are of great importance in defining the mechanism responsible for the development of allergy-associated diseases, such as atopic dermatitis, allergic asthma, and allergic rhinoconjunctivitis. Although these disorders share genetic and environmental risk factors, it is still under debate whether they are linked or develop sequentially along an atopic pathway. The current study was aimed to determine the pattern of allergy sensitization in the Lithuanian birth cohort -Alergemol- n = 1558 established as a part of the multicenter European birth cohort -EuroPrevall-. Early sensitization to food allergens in the -Alergemol- birth cohort was analysed. The analysis revealed 1.3% and 2.8% of symptomatic-sensitized subjects at 6 and 12 months of age, respectively. The sensitization pattern in response to different allergens in the group of infants with food allergy symptoms was studied using allergological methods in vivo and in vitro. The impact of maternal and environmental risk factors on the early development of food allergy in at 6 and 12 months of age was evaluated. Our data showed that maternal diet, diseases, the use of antibiotics, and tobacco smoke during pregnancy had no significant impact on the early sensitization to food allergens. However, infants of atopic mothers were significantly more often sensitized to egg as compared to the infants of nonatopic mothers.

Author: Ruta Dubakiene, Odilija Rudzeviciene, Indre Butiene, Indre Sezaite, Malvina Petronyte, Dalia Vaicekauskaite, and Aurelija Zv



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