Risk of malignant neoplasms in acromegaly: a case–control studyReportar como inadecuado

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Journal of Endocrinological Investigation

, Volume 40, Issue 3, pp 319–322

First Online: 21 October 2016Received: 29 August 2016Accepted: 12 October 2016DOI: 10.1007-s40618-016-0565-y

Cite this article as: Wolinski, K., Stangierski, A., Dyrda, K. et al. J Endocrinol Invest 2017 40: 319. doi:10.1007-s40618-016-0565-y


PurposeAcromegaly is a chronic disease resulting from pathological oversecretion of growth hormone and subsequently insulin growth factor-1. Several complications of the disease have been reported, including cardiovascular diseases, respiratory disorders but also increased risk of benign and malignant neoplasms. The aim of the study was to evaluate the risk of malignant neoplasms in the patients with acromegaly in comparison with the control group.

Patients and methodsMedical documentation of acromegalic patients treated in one medical center between 2005 and 2016 has been analyzed. Results were compared with sex- and age-matched group of subjects with prolactinomas and hormonally inactive pituitary lesions hospitalized in the same department.

ResultsTwo hundred patients with acromegaly were included. Control group was composed of 145 patients. Any malignant neoplasm in anamnesis was present in 27 13.5 % patients with acromegaly and six 4.1 % subjects from control group p = 0.003. Thyroid cancer was present in 14 7.0 % patients with acromegaly and two 1.4 % in control group p = 0.02. Breast cancer was present in seven women 5.4 % of women in acromegaly group but none of subjects in control group p = 0.02. Colon cancer—4 2.0 % patients in acromegaly group and 0 in control group p = 0.14.

ConclusionsMalignant neoplasms are significantly more common in patients with acromegaly. Particularly, risk of thyroid cancer was increased over fivefold. Systematic screening for neoplastic diseases should be important part of follow-up in these patients. Further case–control studies are strongly indicated to evaluate which neoplasms are more common in acromegalic patients and what is the exact risk of malignancy.

KeywordsAcromegaly Thyroid cancer Colon cancer Breast cancer Pituitary K. Wolinski and A. Stangierski have contributed equally to the study.

Autor: K. Wolinski - A. Stangierski - K. Dyrda - K. Nowicka - M. Pelka - A. Iqbal - A. Car - M. Lazizi - N. Bednarek - A. Czarn

Fuente: https://link.springer.com/

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