The Cytotoxic Effect of Magainin II on the MDA-MB-231 and M14K Tumour Cell LinesReportar como inadecuado




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BioMed Research InternationalVolume 2013 2013, Article ID 831709, 11 pages

Research Article

University of Medicine and Pharmacy -Grigore T. Popa-, 700115 Iaşi, Romania

Laboratory of Molecular Biology, Regional Institute of Oncology Iasi, University of Medicine and Pharmacy -Grigore T. Popa-, 700115 Iaşi, Romania

Department of Cell and Molecular Biology, University of Medicine and Pharmacy -Grigore T. Popa-, 700115 Iaşi, Romania

Department of Pathophysiology, University of Medicine and Pharmacy -Grigore T. Popa-, 700115 Iaşi, Romania

Received 26 May 2013; Revised 2 August 2013; Accepted 30 August 2013

Academic Editor: Paul M. Tulkens

Copyright © 2013 Radu Anghel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Many studies have highlighted the tumoricidal properties of some natural peptides known to have antimicrobial virtues. Also, the increasingly higher resistance to conventional antibiotics has become a global public health issue, and the need for new antibiotics has stimulated interest in finding and synthesizing new antimicrobial peptides, which may also be used as chemotherapeutic agents. Relying on the literature, the purpose of our in vitro research was to assess the tumoricidal potential of magainin II on a series of tumour cell lines, namely, MDA-MB-231 breast adenocarcinoma and M14K human mesothelioma. The experimental results of our study revealed that the cytotoxic effects of magainin II depend on its concentration. Its efficiency is significant at 120 μM concentrations, and, although it is much lower, it persists even at 60 μM concentrations. The effects were insignificant at 30 μM concentrations. In our experimental research, the tumoricidal effect of magainin II was not significantly dependent on the type of tumour cell line used.





Autor: Radu Anghel, Daniela Jitaru, Laurenţiu Bădescu, Magda Bădescu, and Manuela Ciocoiu

Fuente: https://www.hindawi.com/



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