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Behavioural Neurology - Volume 18 2007, Issue 1, Pages 1-6

Department of Psychology and Neuroscience, Vita-Salute San Raffaele University, Milan, Italy

Division of Neurology, San Raffaele Turro Hospital, Milan, Italy

USSB—University Statistics Centre for Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy

Received 26 January 2007; Accepted 26 January 2007

Copyright © 2007 Hindawi Publishing Corporation and the authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. The evidence for the clinical effectiveness of cognitive rehabilitation in patients with Alzheimer’s Disease AD is debated. Therefore it is important to collect more evidence about the outcome of non-pharmacological therapy of dementia. Material and Methods. We report data concerning the rehabilitation of 50 patients with probable AD admitted during a 17-month period in a specialized unit. Participants were affected by dementia ranging from mild to severe. The patients were treated with the Reality Orientation Therapy ROT, integrated, when needed, with individualised cognitive approaches. The results concern: the cognitive status, evaluated by means of the Mini Mental State Examination MMSE, the functional status,evaluated with the Activity of Daily Living ADL scale, the assessment of psychological and behavioural disorders measured with the Neuropsychiatry Inventory NPI. The cognitive, functional, and psychopathological assessments were administered at admission and discharge. Results. The mean MMSE scores at admission and discharge were respectively 16.06 and 17.54 Wilcoxon Ranks Test: p = 0.005. Mean ADL scores were 4.86 at admission and 5.02 at discharge p = 0.011. Mean NPI scores were respectively 21.46 and 12.26 p = < 0.001. Conclusions. This survey of the 17-month experience suggests that a comprehensive treatment program may have beneficial effects on cognitive, functional, and in particular neuropsychiatric outcomes. The results should be verified with a randomised clinical trial.

Author: Alberto Raggi, Sandro Iannaccone, Alessandra Marcone, Valeria Ginex, Paola Ortelli, Alessandro Nonis, Maria Cristina Giusti, and



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