Statistical properties of thermodynamically predicted RNA secondary structures in viral genomes - Quantitative Biology > Quantitative MethodsReportar como inadecuado




Statistical properties of thermodynamically predicted RNA secondary structures in viral genomes - Quantitative Biology > Quantitative Methods - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Abstract: By performing a comprehensive study on 1832 segments of 1212 complete genomesof viruses, we show that in viral genomes the hairpin structures ofthermodynamically predicted RNA secondary structures are more abundant thanexpected under a simple random null hypothesis. The detected hairpin structuresof RNA secondary structures are present both in coding and in noncoding regionsfor the four groups of viruses categorized as dsDNA, dsRNA, ssDNA and ssRNA.For all groups hairpin structures of RNA secondary structures are detected morefrequently than expected for a random null hypothesis in noncoding rather thanin coding regions. However, potential RNA secondary structures are also presentin coding regions of dsDNA group. In fact we detect evolutionary conserved RNAsecondary structures in conserved coding and noncoding regions of a large setof complete genomes of dsDNA herpesviruses.



Autor: Marco Spanò, Fabrizio Lillo, Salvatore Miccichè, Rosario N. Mantegna

Fuente: https://arxiv.org/







Documentos relacionados