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Case Reports in MedicineVolume 2009 2009, Article ID 591512, 4 pages

Case Report

Oncologia Medica, Azienda Ospedale Universitaria Careggi, Viale Pieraccini 17, 50139 Firenze, Italy

Dipartimento di Patologia Umana ed Oncologia, Azienda Ospedale Universitaria Careggi, Viale Pieraccini 17, 50139 Firenze, Italy

Received 21 April 2009; Accepted 8 July 2009

Academic Editor: Michael S. Firstenberg

Copyright © 2009 L. Antonuzzo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A 42-year-old man with a cardiac tamponade underwent an urgent pericardiotomy that showed tumoral tissue, covering the surface of the right atrium. The tumor was then partially excised, and the histological examination revealed the presence of a moderately-differentiated angiosarcoma. The patient was then referred to the oncology unit and scheduled for a chemotherapy schedule including Epirubicin 60 mg-m

, on days 1 and 2 plus Ifosfamide 2000 mg-m

, on days 1 to 3 and Uromitexan 2000 mg-m

at hours 0, 4, 8 after IFO. All drugs were administered every three weeks. After two cycles, a restaging work-up revealed a partial remission. The treatment was continued for another two cycles. A new evaluation by cardiac MRI evidenced a local and distant lung progression of disease. The patient died after three months. This paper confirms that cardiac angiosarcoma is a fatal disease, and the prognosis is usually 6–11 months from time of diagnosis.

Author: L. Antonuzzo, V. Rotella, F. Mazzoni, L. Doni, D. Bianchini, F. Garbini, V. Maio, and F. Di Costanzo



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