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Disease Markers - Volume 2016 2016, Article ID 1523959, 6 pages -

Research Article

Department of Cardiology, Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing 100029, China

Departments of Clinical Laboratory, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China

Received 12 January 2016; Accepted 6 March 2016

Academic Editor: Michele Malaguarnera

Copyright © 2016 Tiantong Jiang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To determine the prognostic significance of beta2 microglobulin β2-m concentrations in patients with hemophagocytic lymphohistiocytosis HLH, a rare disorder caused by pathologic activation of the immune system. Patients and Methods. The study population consisted of 74 patients diagnosed with HLH and 35 healthy controls. Serum β2-m levels were measured using a latex agglutination photometric immunoassay. Results. Median serum β2-m levels were significantly higher in HLH patients than in healthy controls 4.05 versus 1.5 mg-L; and were significantly higher in patients with lymphoma associated hemophagocytic syndrome LAHS than in patients with benign disease-associated HLH 4.2 versus 3.3 mg-L; . Higher serum β2-m levels were positively correlated with LAHS , abnormal lactate dehydrogenase concentrations , and hypoalbuminemia . ROC analysis showed that overall survival OS was significantly shorter in LAHS patients with serum β2-m levels ≥4.03 mg-L compared to <4.03 mg-L . Moreover, multivariate analysis showed that serum β2-m level was an independent prognostic of OS in patients with LAHS. Conclusion. High serum β2-m levels and LAHS were associated with markedly poorer OS in patients with HLH. Serum β2-m concentration was a powerful and independent prognostic factor for OS in patients with LAHS.

Autor: Tiantong Jiang, Xiurong Ding, and Weixing Lu



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