International consensus ICON on: clinical consequences of mite hypersensitivity, a global problemReport as inadecuate

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World Allergy Organization Journal

, 10:14

First Online: 18 April 2017Received: 06 January 2017Accepted: 27 February 2017DOI: 10.1186-s40413-017-0145-4

Cite this article as: Sánchez-Borges, M., Fernandez-Caldas, E., Thomas, W.R. et al. World Allergy Organ J 2017 10: 14. doi:10.1186-s40413-017-0145-4


Since mite allergens are the most relevant inducers of allergic diseases worldwide, resulting in significant morbidity and increased burden on health services, the International Collaboration in Asthma, Allergy and Immunology iCAALL, formed by the American Academy of Allergy, Asthma and Immunology AAAAI, the American College of Allergy, Asthma and Immunology ACAAI, the European Academy of Allergy and Clinical Immunology EAACI, and the World Allergy Organization WAO, has proposed to issue an International Consensus ICON on the clinical consequences of mite hypersensitivity. The objectives of this document are to highlight aspects of mite biology that are clinically relevant, to update the current knowledge on mite allergens, routes of sensitization, the genetics of IgE responses to mites, the epidemiologic aspects of mite hypersensitivity, the clinical pictures induced by mites, the diagnosis, specific immunotherapeutic approaches, and prevention.

AbbreviationsAAAAIAmerican academy of allergy asthma and immunology

ACAAIAmerican College of Allergy Asthma and Immunology

DCNPDendritic Cell Associate Nuclear Protein

EAACIEuropean Academy of Allergy and Clinical Immunology

ELISAEnzyme-linked immunosorbent assay

GWASGenome Wide Associations Studies

HDMHouse dust mite

iCAALLInternational Collaboration in Allergy Asthma and Immunology

ICONInternational Consensus on …


IRFInterferon regulatory factor

IUISInternational union of immunological Societies

JAKJanus kinase


LTC4SLeukotriene C4 synthase

MARIAMultiplex array for indoor allergens

MHC-HLAHuman major histocompatibility complex

NOSNitric oxide synthase

PBDProtein database

PKDCCProtein kinase domain containing, cytoplasmic

RASTRadioallergosorbent test

STAT6Signal transducer and activator of transcription 6

TEWLTransepidermal water loss TEWL

TLR-4Toll like receptor 4

TSLPThymic stromal lymphopoietin

WAOWorld Allergy Organization

WHOWorld Health Organization

Author: Mario Sánchez-Borges - Enrique Fernandez-Caldas - Wayne R. Thomas - Martin D. Chapman - Bee Wah Lee - Luis Caraballo - N


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