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Biogerontology

pp 1–20

First Online: 18 April 2017Received: 24 November 2016Accepted: 07 April 2017DOI: 10.1007-s10522-017-9701-0

Cite this article as: Bednarska-Makaruk, M., Graban, A., Wiśniewska, A. et al. Biogerontology 2017. doi:10.1007-s10522-017-9701-0

Abstract

The aim of the study was to determine the role of adiponectin, leptin and resistin in various types of dementia and to investigate their association with inflammatory markers, insulin resistance and abdominal obesity. In 205 patients with dementia 89 with Alzheimer’s disease AD, 47 with vascular dementia VaD, 69 with mixed dementia MD, 113 persons with mild cognitive impairment and in 107 controls serum adiponectin, leptin and resistin levels, pro-inflammatory interleukin-6 IL-6, C-reactive protein hsCRP and chitotriosidase and anti-inflammatory 25-OH vitamin D, HDL-cholesterol and paraoxonase 1 markers, as well as glucose metabolism parameters glucose, insulin and HOMA-IR were determined. In all-cause dementia adiponectin and resistin levels were significantly higher as compared to the controls; leptin levels did not show differences. Higher adiponectin levels concerned AD and MD, whereas higher resistin-VaD and MD. After stratification by abdominal obesity the differences in adiponectin levels remained significant in subjects without obesity. In all-cause dementia negative correlation of adiponectin with obesity, glucose metabolism parameters, IL-6 and hsCRP and positive correlation with HDL-cholesterol were found. Positive correlation of resistin with age, IL-6, hsCRP and chitotriosidase and negative correlation with HDL-cholesterol and paraoxonase 1 were stated. We conclude that dementia of neurodegenerative origin is characterized by elevated adiponectin levels, whereas dementia with vascular changes by increase of resistin. Association with inflammatory indicators may suggest the pro-inflammatory role of resistin in the development of dementia, especially in dementia of vascular mechanism. Identification of this novel biomarker may be important in preventing dementia.

KeywordsAdipokines Dementia Inflammatory markers Abdominal obesity 



Autor: Małgorzata Bednarska-Makaruk - Ałła Graban - Anna Wiśniewska - Wanda Łojkowska - Anna Bochyńska - Magdalena Gugała-Iw

Fuente: https://link.springer.com/







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