Feasibility of uterine preservation in the management of early-stage uterine adenosarcomas: a single institute experienceReport as inadecuate

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World Journal of Surgical Oncology

, 15:87

First Online: 19 April 2017Received: 04 November 2016Accepted: 22 March 2017DOI: 10.1186-s12957-017-1137-0

Cite this article as: Lee, YJ., Kim, DY., Suh, DS. et al. World J Surg Onc 2017 15: 87. doi:10.1186-s12957-017-1137-0


BackgroundWe aimed to evaluate the efficacy and the safety of uterine preservation in patients with early-stage uterine adenosarcoma who want to preserve future fertility.

MethodsWe performed a retrospective review of patients with stage I uterine adenosarcoma diagnosed and treated at a single institute from 1998 through 2014.

ResultsAmong the total of 31 patients, uterine preservation surgery was performed in 7 of the nulliparas. Of the 7 patients receiving uterine preservation surgery, 3 showed no evidence of disease NED, 2 had persistent disease confined to the uterus, and 2 were alive with disease AWD after recurrence. One patient with an NED status had a vaginal delivery at term. In the uterine preservation group, 1 patient had sarcomatous overgrowth at the time of diagnosis and experienced disease recurrence. In the hysterectomy group, 3 of 24 patients had tumor recurrence. Of the five patients with tumor recurrence, four 80% had sarcomatous overgrowth at diagnosis and it was significantly associated with recurrence by univariate analysis OR 13.3, p = 0.027.

ConclusionsUterine preservation represents a possible treatment option for young female patients who want to maintain fertility. However, a detailed explanation of the risk of recurrence is necessary, especially in patients with sarcomatous overgrowth, which seems to be associated with a higher risk of recurrence.

Trial registrationRetrospectively registered.

KeywordsFertility preservation Mullerian adenosarcoma of the uterus Uterine adenosarcoma 

Author: Young-Jae Lee - Dae-Yeon Kim - Dae-Shik Suh - Jong-Hyeok Kim - Yong-Man Kim - Young-Tak Kim - Joo-Hyun Nam

Source: https://link.springer.com/

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