Lack of Association between Pulse Steroid Therapy and Bone Mineral Density in Patients with Multiple SclerosisReport as inadecuate

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Multiple Sclerosis International - Volume 2016 2016, Article ID 5794910, 7 pages -

Research ArticleKaradeniz Technical University, 61080 Trabzon, Turkey

Received 30 September 2015; Revised 7 December 2015; Accepted 13 December 2015

Academic Editor: Bianca Weinstock-Guttman

Copyright © 2016 Serap Zengin Karahan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Multiple sclerosis MS has been associated with reduced bone mineral density BMD. The purpose of this study was to determine the possible factors affecting BMD in patients with MS. We included consecutive 155 patients with MS and 90 age- and sex-matched control subjects. Patients with MS exhibited significantly lower T-scores and Z-scores in the femoral neck and trochanter compared to the controls. Ninety-four 61% patients had reduced bone mass in either the lumbar spine or the femoral neck; of these, 64 41.3% had osteopenia and 30 19.4% had osteoporosis. The main factors affecting BMD were disability, duration of MS, and smoking. There was a negative relationship between femoral BMD and EDSS and disease duration. No association with lumbar BMD was determined. There were no correlations between BMD at any anatomic region and cumulative corticosteroid dose. BMD is significantly lower in patients with MS than in healthy controls. Reduced BMD in MS is mainly associated with disability and duration of the disease. Short courses of high dose steroid therapy did not result in an obvious negative impact on BMD in the lumbar spine and femoral neck in patients with MS.

Author: Serap Zengin Karahan, Cavit Boz, Sevgi Kilic, Nuray Can Usta, Mehmet Ozmenoglu, Vildan Altunayoglu Cakmak, and Sibel Gaziogl



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