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Evidence-Based Complementary and Alternative MedicineVolume 2013 2013, Article ID 535742, 8 pages

Research Article

Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, 16 Nanxiaojie, Dongzhimennei, Beijing 100700, China

Department of Gastroenterology, Peking University First Hospital, 6 Xishiku Street, Beijing 100034, China

Institute of Basic and Clinic Medicine, China Academy of Chinese Medical Sciences, 16 Nanxiaojie, Dongzhimennei, Beijing 100700, China

Received 26 March 2013; Revised 8 June 2013; Accepted 17 June 2013

Academic Editor: Yi-Hung Chen

Copyright © 2013 Yang-Shuai Su et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of this study was to explore the -intensity-response- relationship between EAS and the effect of gastric motility of rats and its underlying peripheral neural mechanism by employing ASIC3 knockout ASIC3−-−, TRPV1 knockout TRPV1−-−, and C57BL-6 mice. For adult male Sprague-Dawley rats, the intensities of EAS were 0.5, 1, 3, 5, 7, and 9 mA, respectively. For mice in each group, only 1 mA was used, by which C fiber of the mice can be activated. Gastric antrum motility was measured by intrapyloric balloon. Gastric motility was facilitated by EAS at ST36 and inhibited by EAS at CV12. The half maximal facilitation intensity of EAS at ST36 was 2.1–2.3 mA, and the half maximal inhibitory intensity of EAS at CV12 was 2.8 mA. In comparison with C57BL-6 mice, the facilitatory effect of ST36 and inhibitive effect of CV12 in ASIC3−-− mice decreased, but the difference was not statistically significant . However, these effects in TRPV1−-− mice decreased significantly . The results indicated that there existed an -intensity-response- relationship between EAS and the effect of gastric motility. TRPV1 receptor was involved in the regulation of gastric motility of EAS.





Autor: Yang-Shuai Su, Wei He, Chi Wang, Hong Shi, Yu-Feng Zhao, Juan-Juan Xin, Xiao-Yu Wang, Hong-Yan Shang, Ling Hu, Xiang-Hong

Fuente: https://www.hindawi.com/



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