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, 9:7

First Online: 25 April 2017Received: 21 November 2016Accepted: 03 April 2017DOI: 10.1186-s41479-017-0031-4

Cite this article as: Phuong, N.T.K., Hoang, T.T., Van, P.H. et al. Pneumonia 2017 9: 7. doi:10.1186-s41479-017-0031-4


Globally, pneumonia is considered to be the biggest killer of infants and young children aged <5 years outside the neonatal period, with the greatest disease burden in low- and middle-income countries. Optimal management of childhood pneumonia is challenging in settings where clinicians have limited information regarding the local pathogen and drug resistance profiles. This frequently results in unnecessary and poorly targeted antibiotic use. Restricting antibiotic use is a global priority, particularly in Asia and the Western Pacific Region where excessive use is driving high rates of antimicrobial resistance. The authors conducted a comprehensive literature review to explore the antibiotic resistance profile of bacteria associated with pneumonia in the Western Pacific Region, with a focus on Vietnam. Current management practices were also considered, along with the diagnostic dilemmas faced by doctors and other factors that increase unnecessary antibiotic use. This review offers some suggestions on how these issues may be addressed.

AbbreviationsARTIAcute respiratory tract infection

AMRAntimicrobial resistance

CRPC-reactive protein

CLSIClinical and Laboratory Standards Institute

CIConfidence interval

EUCASTEuropean Committee on Antimicrobial Susceptibility Testing

H. influenzaeHaemophilus influenzae

HibHaemophilus influenzae type b

hVISAHeterogeneous vancomycin-intermediate S.aureus

MRSAMethicillin resistant staphylococcus aureus

MICMinimal inhibitory concentration

M. pneumoniaeMycoplasma pneumonia


PCVPneumococcal conjugate vaccine


S. aureusStaphylococcus aureus

S. pneumoniaeStreptococcus pneumoniae

VINARESVietnam resistance project

WHOWorld Health Organization

Autor: Nguyen T. K. Phuong - Tran T. Hoang - Pham H. Van - Lolyta Tu - Stephen M. Graham - Ben J. Marais

Fuente: https://link.springer.com/

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