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Biological Procedures Online

, 19:3

First Online: 27 April 2017Received: 01 September 2016Accepted: 06 April 2017DOI: 10.1186-s12575-017-0052-7

Cite this article as: Mumtaz, P.T., Bhat, S.A., Ahmad, S.M. et al. Biol Proced Online 2017 19: 3. doi:10.1186-s12575-017-0052-7

Abstract

Immune responses combat various infectious agents by inducing inflammatory responses, antimicrobial pathways and adaptive immunity. The polygenic responses to these external stimuli are temporally and coordinately regulated. Specific lncRNAs are induced to modulate innate and adaptive immune responses which can function through various target interactions like RNA-DNA, RNA-RNA, and RNA-protein interaction and hence affect the immunogenic regulation at various stages of gene expression. LncRNA are found to be present in various immune cells like monocytes, macrophages, dendritic cells, neutrophils, T cells and B cells. They have been shown to be involved in many biological processes, including the regulation of the expression of genes, the dosage compensation and genomics imprinting, but the knowledge how lncRNAs are regulated and how they alter cell differentiation-function is still obscure. Further dysregulation of lncRNA has been seen in many diseases, but as yet very less research has been carried out to understand the role of lncRNAs in regulation during host-pathogens interactions. In this review, we summarize the functional developments and mechanism of action of lncRNAs, in immunity and defense of host against pathogens.

KeywordsLncRNA Immunity Practical miscellany Immunogene expression host-pathogen interaction AbbreviationsCCTFCCCTC Binding factor

CK1Casein kinase 1

DCsDendritic Cells

DNADeoxyribonucleic acid

DYRKDual-specificity tyrosine phosphorylation-regulated kinase

eRNAEnhancer Ribonucleic acid

GSK3Glycogen synthase kinase 3.

HOTAIRM1HOX Antisense Intergenic RNA myeloid 1

HSVHerpes Simplex Virus

ISGsInterferon Stimulated Genes

LncRNAslong non coding Ribonucleic acids

LPSLipopolysaccharide

MDRVMuscovy Duck Reovirus

mRNAMessenger Ribonucleic acid

NEAT1Nuclear Enriched Abundant Transcript 1

NFATNuclear Factor Of Activated T-Cells

NRAVNegative Regulator Of Antiviral

NTTNon coding Transcript in T-Cells

PAN RNAPolyadenylated Nuclear Ribonucleic acid

PBMNCPeripheral Blood Mononuclear Cells

RBPRibonucleic acid Binding Protiens

RNARibonucleic acid

rRNARibosomal Ribonucleic acid

SeVSendai Virus

shRNAshort hairpin Ribonucleic acid

snoRNASmall nucleolar Ribonucleic acid

snRNASmall nuclear Ribonucleic acid

STAT3Signal Transducer And Activator Of Transcription 3

TMEVPG1Theiler’s Murine Encephalomyelitis Virus Persistence Candidate Gene 1

tRNATranscriptional Ribonucleic acid

VINCI1Virus Inducible Non Coding Ribonucleic Acid





Autor: Peerzada Tajamul Mumtaz - Shakil Ahmad Bhat - Syed Mudasir Ahmad - Mashooq Ahmad Dar - Raashid Ahmed - Uneeb Urwat - Aad

Fuente: https://link.springer.com/







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