A Systems Approach to the Proteomic Identification of Novel Cancer BiomarkersReport as inadecuate

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Disease Markers - Volume 28 2010, Issue 4, Pages 233-239

Fred Hutchinson Cancer Research Center, Seattle, WA, USA

Received 31 May 2010; Accepted 31 May 2010

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The proteomics field has experienced rapid growth with technologies achieving ever increasing accuracy, sensitivity, and throughput, and with availability of computational tools to address particular applications. Given that the proteome represents the most functional component encoded for in the genome, a systems approach to disease investigations and biomarker identification benefits substantially from integration of proteome level studies. Here we present proteomic approaches that have allowed systematic searches for potential cancer markers by integrating cancer cell profiling with additional sources of data, as illustrated with recent studies of ovarian cancer.

Author: Sharon Pitteri and Sam Hanash

Source: https://www.hindawi.com/


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