3D SPECT-CT fusion using image data projection of bone SPECT onto 3D volume-rendered CT images: feasibility and clinical impact in the diagnosis of bone metastasisReportar como inadecuado




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Annals of Nuclear Medicine

, Volume 31, Issue 4, pp 304–314

First Online: 27 February 2017Received: 27 November 2016Accepted: 05 February 2017DOI: 10.1007-s12149-017-1158-3

Cite this article as: Ogata, Y., Nakahara, T., Ode, K. et al. Ann Nucl Med 2017 31: 304. doi:10.1007-s12149-017-1158-3

Abstract

PurposeWe developed a method of image data projection of bone SPECT into 3D volume-rendered CT images for 3D SPECT-CT fusion. The aims of our study were to evaluate its feasibility and clinical usefulness.

MethodsWhole-body bone scintigraphy WB and SPECT-CT scans were performed in 318 cancer patients using a dedicated SPECT-CT systems. Volume data of bone SPECT and CT were fused to obtain 2D SPECT-CT images. To generate our 3D SPECT-CT images, colored voxel data of bone SPECT were projected onto the corresponding location of the volume-rendered CT data after a semi-automatic bone extraction. Then, the resultant 3D images were blended with conventional volume-rendered CT images, allowing to grasp the three-dimensional relationship between bone metabolism and anatomy. WB and SPECT WB + SPECT, 2D SPECT-CT fusion, and 3D SPECT-CT fusion were evaluated by two independent reviewers in the diagnosis of bone metastasis. The inter-observer variability and diagnostic accuracy in these three image sets were investigated using a four-point diagnostic scale.

ResultsIncreased bone metabolism was found in 744 metastatic sites and 1002 benign changes. On a per-lesion basis, inter-observer agreements in the diagnosis of bone metastasis were 0.72 for WB + SPECT, 0.90 for 2D SPECT-CT, and 0.89 for 3D SPECT-CT. Receiver operating characteristic analyses for the diagnostic accuracy of bone metastasis showed that WB + SPECT, 2D SPECT-CT, and 3D SPECT-CT had an area under the curve of 0.800, 0.983, and 0.983 for reader 1, 0.865, 0.992, and 0.993 for reader 2, respectively WB + SPECT vs. 2D or 3D SPECT-CT, p < 0.001; 2D vs. 3D SPECT-CT, n.s

The durations of interpretation of WB + SPECT, 2D SPECT-CT, and 3D SPECT-CT images were 241 ± 75, 225 ± 73, and 182 ± 71 s for reader 1 and 207 ± 72, 190 ± 73, and 179 ± 73 s for reader 2, respectively. As a result, it took shorter time to read 3D SPECT-CT images than 2D SPECT-CT p < 0.0001 or WB + SPECT images p < 0.0001.

Conclusions3D SPECT-CT fusion offers comparable diagnostic accuracy to 2D SPECT-CT fusion. The visual effect of 3D SPECT-CT fusion facilitates reduction of reading time compared to 2D SPECT-CT fusion.

KeywordsSPECT-CT Volume rendering Three-dimensional Image fusion Bone metastasis 



Autor: Yuji Ogata - Tadaki Nakahara - Kenichi Ode - Yohji Matsusaka - Mari Katagiri - Yu Iwabuchi - Kazunari Itoh - Akira Ichimur

Fuente: https://link.springer.com/







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