Activation Effects of Polysaccharides of Flammulina velutipes Mycorrhizae on the T Lymphocyte Immune FunctionReportar como inadecuado




Activation Effects of Polysaccharides of Flammulina velutipes Mycorrhizae on the T Lymphocyte Immune Function - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Journal of Immunology Research - Volume 2014 2014, Article ID 285421, 7 pages -

Research Article

College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China

Engineering Research Center of Edible and Medicinal Fungi, Ministry of Education, Jilin Agricultural University, Changchun 130118, China

Received 26 March 2014; Revised 29 June 2014; Accepted 30 June 2014; Published 13 July 2014

Academic Editor: Mario Clerici

Copyright © 2014 Zheng-Fei Yan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Flammulina velutipes mycorrhizae have increasingly been produced with increasing of F. velutipes production. A mouse model was thus used to examine potential effect of F. velutipes mycorrhizae on the immune function. Fifty female Wistar mice 5-weeks-old weighed 15–20 g were randomly allocated into five groups. Polysaccharide of F. velutipes mycorrhizae were treated with mice and mice spleen lymphocytes. The levels of CD3

, CD4

, and CD8

T lymphocyte, interleukin-2 IL-2, and tumor necrosis factor-a TNF- were determined. The results showed that the proportions of CD3

, and CD4

T lymphocyte, the ratio of CD4

-CD8

, and the levels of IL-2 and TNF-a were significantly increased in polysaccharide of F. velutipes mycorrhizae, while the proportion of CD8

T lymphocyte was decreased in polysaccharide of F. velutipes mycorrhizae-dose dependent manner. Our findings indicated that a long term exposure of polysaccharide of F. velutipes mycorrhizae could activate the T lymphocyte immune function. Polysaccharide of F. velutipes mycorrhizae was expected to develop into the immune health products.





Autor: Zheng-Fei Yan, Nai-Xu Liu, Xin-Xin Mao, Yu Li, and Chang-Tian Li

Fuente: https://www.hindawi.com/



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