A Proven Case of Cutaneous Rhizopus Infection Presenting with Severe Limb Pain Very Soon after Induction Treatment in a Patient with Acute Lymphoblastic LeukemiaReportar como inadecuado




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Case Reports in Hematology - Volume 2015 2015, Article ID 285360, 4 pages -

Case Report

Department of Hematology, Gazi University Faculty of Medicine, Ankara, Turkey

Department of Infectious Disease, Gazi University Faculty of Medicine, Ankara, Turkey

Department of Pathology, Gazi University Faculty of Medicine, Ankara, Turkey

Department of Microbiology, Gazi University Faculty of Medicine, Ankara, Turkey

Department of Orthopedics, Gazi University Faculty of Medicine, Ankara, Turkey

Department of Radiology, Gazi University Faculty of Medicine, Ankara, Turkey

Received 25 October 2014; Revised 11 January 2015; Accepted 12 January 2015

Academic Editor: Kazunori Nakase

Copyright © 2015 Mehmet Sezgin Pepeler et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective and Importance. Invasive mucormycosis may complicate the course of patients with hematologic malignancies and has a very high mortality rate. Early diagnosis and aggressive approach combined with surgical and medical treatment have paramount importance for cure. Clinical Presentation. We report here a case of a patient with acute lymphoblastic leukemia presenting with a subcutaneous mass lesion which was sampled by an ultrasound guided needle biopsy. The pathology showed microorganisms with aseptate hyphae with wide, irregular walls and more or less branching with highly vertical angles which suggested a mold infection. The specimen was also cultured where Rhizopus spp. grew. Conclusion. Posaconazole 200 mg QID was commenced. She recovered from neutropenia and pain on day 20 of treatment. After 4 courses of hyper-CVAD chemotherapy, the remaining soft tissue mass was removed surgically and she underwent allogeneic HSCT from a full matched sibling donor under secondary prophylaxis.





Autor: Mehmet Sezgin Pepeler, Kadir Acar, Özlem Güzel Tunçcan, Ömer Uluoğlu, Ayşe Kalkancı, Hakan Atalar, Koray Kılıç, a

Fuente: https://www.hindawi.com/



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