Significantly higher faecal counts of the yeasts candida and saccharomyces identified in people with coeliac diseaseReportar como inadecuado




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Gut Pathogens

, 9:26

First Online: 05 May 2017Received: 19 February 2017Accepted: 20 April 2017DOI: 10.1186-s13099-017-0173-1

Cite this article as: Harnett, J., Myers, S.P. & Rolfe, M. Gut Pathog 2017 9: 26. doi:10.1186-s13099-017-0173-1

Abstract

BackgroundCoeliac disease is an autoimmune disorder resulting from an interaction between diet, genome and immunity. The treatment of CoeD is lifelong adherence to a gluten free diet, which is associated with clinical and histological improvements. However, a substantive number of individuals report only partial symptom improvement despite both compliance with a strict gluten free diet and improvements in serological and histological biomarkers of disease activity. The role of the intestinal microbiota is an area of interest in this sub-group.

AimsTo investigate the role of yeasts and parasites in individuals reporting persistent symptoms of Coeliac disease CoeD.

MethodsForty-five people who met the ESPGHAN diagnostic criteria for CoeD were recruited via the Australian Coeliac Association. The faecal measures of the DNA of yeasts and parasites from the CoeD group were compared to data obtained from the medical records of non-coeliac controls with gastrointestinal symptoms from other causes.

ResultsCandida sp. was detected in 33% of the CoeD group compared 0% of the control group p = 0.000 and Saccharomyces sp. was detected in 33% of the CoeD group compared to 10% of the control group p = 0.026. There were no differences in the presence of any of the parasite species measured.

ConclusionFurther research is required to understand the significance of Candida and Saccharomyces species in both the aetiology of CoeD and of persistent symptoms in this sub-group.

Trial Registration Clinical Trial Registration—ANZCTR Number: 12610000630011

KeywordsCoeliac disease Microbiota Yeasts Candida Saccharomyces AbbreviationsACAAustralian Coeliac Association

ASCAsanti-saccharomyces cerevisiae antibodies

ANOVAanalysis of variance

CDQCoeliac Disease Questionnaire

CoeDcoeliac disease

CFUscolony forming units

GAgeorgia

GEEGeneralised Estimated Equations

GFDgluten free diet

IBDinflammatory bowel disease

ILinterleukin

IFNinterferon

NAnot available

NATANational Association of Testing Authorities

NSWNew South Wales

RCTRandomised Controlled Trial

TGFtransforming growth factor

TNFtumour necrosis factor

UACunable to calculate





Autor: Joanna Harnett - Stephen P. Myers - Margaret Rolfe

Fuente: https://link.springer.com/







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