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International Journal of PeptidesVolume 2010 2010, Article ID 248948, 11 pages

Review Article

Department of Clinical Nutrition, Food and Health Research Centre, University of Eastern Finland, Kuopio Campus, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Campus P.O. Box 1627 FI-70211 Kuopio, Finland

Institute of Clinical Medicine, Department of Internal Medicine, Biocenter Oulu, 90014 University of Oulu and Research Center of Oulu University Hospital, Oulu, Finland

Received 4 November 2009; Accepted 9 February 2010

Academic Editor: Alessandro Laviano

Copyright © 2010 Leena Pulkkinen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Metabolic syndrome is a cluster of related risk factors for cardiovascular disease, type 2 diabetes and liver disease. Obesity, which has become a global public health problem, is one of the major risk factors for development of metabolic syndrome and type 2 diabetes. Obesity is a complex disease, caused by the interplay between environmental and genetic factors. Ghrelin is one of the circulating peptides, which stimulates appetite and regulates energy balance, and thus is one of the candidate genes for obesity and T2DM. During the last years both basic research and genetic association studies have revealed association between the ghrelin gene and obesity, metabolic syndrome or type 2 diabetes

Author: Leena Pulkkinen, Olavi Ukkola, Marjukka Kolehmainen, and Matti Uusitupa



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