Synthesis, crystallographic, spectroscopic studies and biological activity of new cobaltII complexes with bioactive mixed sulindac and nitrogen-donor ligandsReportar como inadecuado




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Chemistry Central Journal

, 11:40

Inorganic Chemistry

Abstract

Four novel complexes CoH2O4sul2 1 , Co2-ampy2sul2 2 , CoH2O21,10-phen sul2 3 and Co2,9-dimephensul2 4 sul = sulindac, 2-ampy = 2-amino pyridine, 1,10-phen = 1,10-phenanthroline and 2,9-dimeph = 2,9-dimethyl-1,10-phenanthroline were prepared and characterized by IR, UV–Visible spectroscopy and magnetic properties. The crystal structures of complexes 1 and 4 were determined by single-crystal X-ray diffraction. In-vitro anti-bacterial activity for the prepared complexes against Gram-positive Staphylococcus epidermidis, Staphylococcus aureus and Gram-negative Bordetella, Escherichia coli bacteria and Yeast species Saccharomyces and Candida were performed using agar well-diffusion method. Only complex 4 showed reasonable activity against yeast. All compounds showed more anti-bacterial activity against Gram-positive bacteria than Gram-negative.Open image in new windowGraphical abstractThis work reports synthesis, crystallographic, spectroscopic studies and biological activity of new cobaltII complexes with bioactive mixed sulindac and nitrogen-donor ligands. The crystal structures of complexes 1 and 4 were determined using single-crystal X-ray diffraction.In-vitro anti-bacterial activity of the prepared complexes and their parent ligands were investigated against different Gram-positive and Gram-negative bacteria using agar diffusion method

KeywordsCobaltII complexes Nitrogen donor ligands Sulindac Anti-bacterial activity Electronic supplementary materialThe online version of this article doi:10.1186-s13065-017-0268-2 contains supplementary material, which is available to authorized users.

Asia M. Shalash and Hijazi I. Abu Ali contributed equally to this work





Autor: Asia M. Shalash - Hijazi I. Abu Ali

Fuente: https://link.springer.com/







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