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Radiation Oncology

, 12:82

Clinical Radiation Oncology


Background and PurposeThis review aims to provide a comprehensive overview of the literature and elucidate open questions for future clinical trials concerning diagnostics and treatment modalities for cervical cancer of unknown primary CUP.

MethodsA literature search for head and neck CUP was performed with focus on diagnostics and therapies as well as molecular markers.

ResultsHigh level evidence on CUP is limited. However, it seems that a consensus exists regarding the optimal diagnostic procedures. The correct implementation of biomarkers for patient stratification and treatment remains unclear. An even greater dispute dominates about the ideal treatment with publications ranging from sole surgery to surgery with postoperative bilateral radiotherapy with inclusion of the mucosa and concomitant chemotherapy.

ConclusionsCervical CUP represents a very heterogeneous malignant disease. On this account many aspects concerning treatment optimization remain unclear, despite a considerable number of publications in the past. Future research in form of prospective randomized trials is needed in order to better define patient stratification criteria and enable tailored treatment.

KeywordsCUP Cancer of unknown primary Cervical Lymph node Head and neck cancer AbbreviationsCRTChemoradiotherapy

CTComputer tomography


CUPCancer of unknown primary

DFSDisease free survival

EBVEpstein-Barr virus

ECEExtracapsular extention

FDG-PET18F-fluoro2-deoxyglucose positron emission tomography

FNABFine-needle aspiration biopsy

HNCUPCUP in the head and neck region

HNSCCHead and neck squamous cell carcinoma

HPVHuman papilloma virus


IMRTIntensity modulated radiotherapy

MRIMagnet resonance imaging

NCCNNational Comprehensive Cancer Network

NPCNasopharyngeal carcinoma

OSOverall survival

P-UADTPanendoscopy of the upper aerodigestive tract

qRT-PCRquantitative reverse transcriptase-PCR


SCCSquamous cell carcinoma

UICCUnion Internationale Contre le Cancer

Author: Jens Müller von der Grün - Aykut Tahtali - Shahram Ghanaati - Claus Rödel - Panagiotis Balermpas

Source: https://link.springer.com/

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