Current status and perspectives of patient-derived xenograft models in cancer researchReport as inadecuate

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Journal of Hematology and Oncology

, 10:106

First Online: 12 May 2017Received: 15 March 2017Accepted: 22 April 2017DOI: 10.1186-s13045-017-0470-7

Cite this article as: Lai, Y., Wei, X., Lin, S. et al. J Hematol Oncol 2017 10: 106. doi:10.1186-s13045-017-0470-7


Cancers remain a major public health problem worldwide, which still require profound research in both the basic and preclinical fields. Patient-derived xenograft PDX models are created when cancerous cells or tissues from patients’ primary tumors are implanted into immunodeficient mice to simulate human tumor biology in vivo, which have been extensively used in cancer research. The routes of implantation appeared to affect the outcome of PDX research, and there has been increasing applications of patient-derived orthotopic xenograft PDOX models. In this review, we firstly summarize the methodology to establish PDX models and then go over recent application and function of PDX models in basic cancer research on the areas of cancer characterization, initiation, proliferation, metastasis, and tumor microenvironment and in preclinical explorations of anti-cancer targets, drugs, and therapeutic strategies and finally give our perspectives on the future prospects of PDX models.

KeywordsPDX models Basic Preclinical Cancer research Drugs AbbreviationsCTCsCirculating tumor cells

FGSPrecise fluorescence-guided surgery

HCCHepatocellular carcinoma

NSCLCNon-small cell lung cancer

PDXPatient-derived xenograft

Author: Yunxin Lai - Xinru Wei - Shouheng Lin - Le Qin - Lin Cheng - Peng Li



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