Effects of Hyul-Bu-Chuke-Tang on Erythrocyte Deformability and Cerebrovascular CO2 Reactivity in Normal SubjectsReportar como inadecuado

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Evidence-Based Complementary and Alternative MedicineVolume 2012 2012, Article ID 725241, 7 pages

Research ArticleDepartment of Cardiovascular and Neurologic Diseases, College of Korean Medicine, Kyung Hee University, Seoul 130-702, Republic of Korea

Received 19 December 2011; Revised 24 March 2012; Accepted 1 April 2012

Academic Editor: Il-Moo Chang

Copyright © 2012 Woo-Sang Jung et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim. Hyul-bu-chuke-tang HCEt is a well-known traditional herbal medicine that is used for the treatment of ischemic cerebrovascular disorders. We investigated the acute effects of HCEt on erythrocyte deformability and cerebrovascular CO2 reactivity CVR in healthy male subjects. Materials and Methods. We examined erythrocyte deformability in an HCEt group and a control group . CVR was measured using hyperventilation-induced CO2 reactivity of the middle cerebral artery and transcranial Doppler TCD in the HCEt group . A historical control group of CVR measurements was also created from our previous study. All measurements were performed prior to and 1, 2, and 3 hours after HCEt administration. Results. HCEt significantly improved erythrocyte deformability 1 hour after administration compared to the control group % versus %, . HCEt significantly improved the CVR 2 hours after administration compared to the historical control group % versus %, . The mean blood pressure and pulse rate did not vary from baseline values in either group. Conclusions. We demonstrated that HCEt improved erythrocyte deformability and CVR. Our findings suggest that an improvement in erythrocyte deformability contributes to HCEt’s effect on cerebral microcirculation.

Autor: Woo-Sang Jung, Joo-Young Park, Hyung-Sik Byeon, Young-Jee Kim, Jung-Mi Park, Seong-Uk Park, Seung-Yeon Cho, and Sang-Kwan M

Fuente: https://www.hindawi.com/


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