The effect of hemostatic dressing prototypes for the uniformed services on selected blood coagulation parameters in pigsReportar como inadecuado




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Acta Veterinaria Scandinavica

, 59:29

First Online: 12 May 2017Received: 13 June 2016Accepted: 03 May 2017DOI: 10.1186-s13028-017-0297-9

Cite this article as: Adamiak, Z., Krystkiewicz, W., Pomianowski, A. et al. Acta Vet Scand 2017 59: 29. doi:10.1186-s13028-017-0297-9

Abstract

BackgroundSerious injuries accompanied by severe bleeding are life-threatening. Post-traumatic hemorrhage involves the risk of developing coagulopathy. Hemostatic dressings are widely used to minimize bleeding. The application of procoagulants in control of hemorrhage may lead to thrombosis or disseminated intravascular coagulation. The aim of this study was to evaluate the effect of hemostatic dressing prototypes on the porcine coagulation system.

ResultsFibrinogen and d-dimer concentrations were significantly higher in the experimental groups where hemostatic dressings were used in comparison with the control group. Considerable differences in antithrombin III activity and thrombin–antithrombin complex concentrations were also observed between groups.

ConclusionsThe hemostatic dressing comprising modified seton impregnated with 18.0 g-m of procoagulant was most effective in preserving the physiological equilibrium between fibrinogenesis and fibrinolysis.

KeywordsHemorrhage Hemostatic dressing Pigs AbbreviationsAPTTactivated partial thromboplastin time

ATIIIantithrombin III activity

ChitoClear hqg 95initial chitosan

DDd-dimer concentrations

DICdisseminated intravascular coagulation

EDTAK2ethylenediaminetetraacetic acid dipotassium salt dihydrate

FIBfibrinogen concentrations

Hcthematocrit

Hgbhemoglobin concentrations

MCHmean corpuscular hemoglobin

MCHCmean corpuscular hemoglobin concentrations

MCVmean corpuscular volume

MPVmean platelet volume

OBR-G-Sdressing material sponge made of Na–Ca chitosan-algal composite microfibers and nanofibers

OBR-MBTtactic gauze modified with a polymer mixture of Na–Ca chitosan-algal composite microfibers and nanofibers

OBR-MS-Sseton gauze modified with a polymer mixture of Na–Ca chitosan-algal composite microfibers and nanofibers

PLTplatelet counts

Protanal LF10-60-FTinitial alginate

PTprothrombin time

RBCred blood cell counts

TATthrombin–antithrombin complex concentrations

TTthrombin time

WBCwhite blood cell counts





Autor: Zbigniew Adamiak - Wioletta Krystkiewicz - Andrzej Pomianowski - Danuta Bukowiecka - Waldemar Zubrzycki - Marek Jałyński -

Fuente: https://link.springer.com/







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