Gene variants in the FTO gene are associated with adiponectin and TNF-alpha levels in gestational diabetes mellitusReportar como inadecuado




Gene variants in the FTO gene are associated with adiponectin and TNF-alpha levels in gestational diabetes mellitus - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Diabetology and Metabolic Syndrome

, 9:32

First Online: 12 May 2017Received: 08 March 2017Accepted: 05 May 2017DOI: 10.1186-s13098-017-0234-0

Cite this article as: Saucedo, R., Valencia, J., Gutierrez, C. et al. Diabetol Metab Syndr 2017 9: 32. doi:10.1186-s13098-017-0234-0

Abstract

BackgroundObesity may have a role in the development of gestational diabetes mellitus GDM. Single-nucleotide-polymorphisms SNPs of the FTO fat mass and obesity associated gene have been associated with obesity. The aim of this study was to investigate SNPs rs8050136, rs9939609, and rs1421085 of the FTO gene in women with GDM and their associations with maternal pre-pregnancy weight and body mass index, gestational weight gain and mediators of insulin resistance in GDM like leptin, adiponectin, ghrelin and tumor necrosis factor-alpha TNF-alpha, compared with healthy pregnant controls.

Methods80 women with GDM and 80 women with normal pregnancy were considered for the present study. Genotyping of selected SNPs in all study subjects was done using the Taq-Man assay and the adipokines and ghrelin were measured by immunoassays. Chi square test, odds ratios OR and their respective 95% confidence intervals were used to measure the strength of association between FTO SNPs and GDM.

ResultsThere was no association among FTO SNPs and GDM. Interestingly, in GDM group, women carrying the risk alleles of the three SNPs had increased TNF-alpha, and decreased adiponectin levels; these associations remained significant after adjusting for pre-gestational body weight and age. Moreover, the risk allele of rs1421085 was also associated with increased weight gain during pregnancy.

ConclusionsThe FTP SNPs rs8050136, rs9939609, and rs1421085 are not a major genetic regulator in the etiology of GDM in the studied ethnic group. However, these SNPs were associated with adiponectin and TNF-alpha concentrations in GDM subjects.

KeywordsAdipokines FTO Gestational diabetes Obesity Single nucleotide polymorphism AbbreviationsGDMgestational diabetes mellitus

SNPssingle-nucleotide-polymorphisms

FTOfat mass and obesity associated

BMIbody mass index

TNF-alphatumor necrosis factor-alpha

ORodds ratio

OECDOrganisation for Economic Co-operation and Development

GWASgenome-wide association studies

DNAdeoxyribonucleic acid

PCRpolymerase chain reaction

HOMA-IRhomeostasis model assessment index

CIconfidence intervals

ANCOVAanalysis of covariance

HWHardy–Weinberg

LDlinkage disequilibrium

T2Dtype 2 diabetes

CRPC-reactive protein

SATsubcutaneous adipose tissue

IRS-1insulin receptor substrate

IRinsulin receptor





Autor: Renata Saucedo - Jorge Valencia - Claudia Gutierrez - Lourdes Basurto - Marcelino Hernandez - Edgardo Puello - Guadalupe Ri

Fuente: https://link.springer.com/







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