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Surgical Case Reports

, 3:68

First Online: 12 May 2017Received: 10 January 2017Accepted: 05 May 2017DOI: 10.1186-s40792-017-0344-9

Cite this article as: Tada, K., Etoh, T., Shitomi, Y. et al. surg case rep 2017 3: 68. doi:10.1186-s40792-017-0344-9


BackgroundAlthough chemotherapy is the first recommended treatment of unresectable gastric cancer, a pathological complete response is a rare event.

Case presentationA 58-year-old male was diagnosed as gastric cancer with a bulky tumor, lymphadenopathy, and suspicious peritoneal dissemination. The patient underwent chemotherapy with S-1 and cisplatin. After three courses of chemotherapy, a computed tomography showed dramatic improvements in gastric wall thickening, shrinkage of lymphadenopathy, and disappearance of disseminated peritoneal lesion. The patient underwent potentially curative resection by total gastrectomy with D2 lymph node dissection. Histological examination revealed the absence of malignant cells not only in the resected specimen but also in the harvested lymph nodes. At present, more than 7 years after the initial surgery, the patient is still alive without any recurrence.

ConclusionsWe obtained a pathological complete response by chemotherapy with S-1 and cisplatin for advanced gastric cancer. Although a pathological complete response is a rare event, it would be associated with the long-term survival of patients with advanced gastric cancer.

KeywordsPathological complete response Long-term survival Advanced gastric cancer Abbreviations5-FU5-Fluorouracil

CTComputed tomography

pCRPathological complete response

PETPositron emission tomography

RECISTResponse Evaluation Criteria in Solid Tumors

S-1Tegafur-gimeracil-oteracil potassium

Autor: Kazuhiro Tada - Tsuyoshi Etoh - Yuki Shitomi - Yoshitake Ueda - Manabu Tojigamori - Hidefumi Shiroshita - Norio Shiraishi -

Fuente: https://link.springer.com/

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