Weekly screening supports terminating nosocomial transmissions of vancomycin-resistant enterococci on an oncologic ward – a retrospective analysisReportar como inadecuado




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Antimicrobial Resistance and Infection Control

, 6:48

First Online: 16 May 2017Received: 06 February 2017Accepted: 10 May 2017DOI: 10.1186-s13756-017-0206-z

Cite this article as: Kampmeier, S., Knaack, D., Kossow, A. et al. Antimicrob Resist Infect Control 2017 6: 48. doi:10.1186-s13756-017-0206-z

Abstract

BackgroundTo investigate the impact of weekly screening within the bundle of infection control measures to terminate vancomycin-resistant enterococci VRE transmissions on an oncologic ward.

MethodsA cluster of 12 VRE colonisation and five infections was detected on an oncologic ward between January and April 2015. Subsequently, the VRE point prevalence was detected and, as part of a the bundle of infection control strategies to terminate the VRE cluster, we isolated affected patients, performed hand hygiene training among staff on ward, increased observations by infection control specialists, intensified surface disinfection, used personal protective equipment and initiated an admission screening in May 2015. After a further nosocomial VRE infection in August 2015, a weekly screening strategy of all oncology patients on the respective ward was established while admission screening was continued. Whole genome sequencing WGS-based typing was applied to determine the clonal relationship of isolated strains.

ResultsInitially, 12 of 29 patients were VRE colonised; of these 10 were hospital-acquired. During May to August, on average 7 of 40 patients were detected to be VRE colonised per week during the admission screening, showing no significant decline compared to the initial situation. WGS-based typing revealed five different clusters of which three were due to vanB- and two vanA-positive enterococci. After an additional weekly screening was established, the number of colonised patients significantly declined to 1-53 and no further nosocomial cases were detected.

ConclusionsWeekly screening helped to differentiate between nosocomial and community-acquired VRE cases resulting in earlier infection control strategies on epidemic situations for a successful termination of nosocomial VRE transmissions.

KeywordsVancomycin-resistant enterococci E. faecium Screening Infection control bundle strategies Outbreak Whole genome sequencing AbbreviationscgMLSTCore genome multilocus sequence typing

VREVancomycin-resistant enterococci

WGSWhole genome sequencing





Autor: Stefanie Kampmeier - Dennis Knaack - Annelene Kossow - Stefanie Willems - Christoph Schliemann - Wolfgang E. Berdel - Frank

Fuente: https://link.springer.com/







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