A Comparison of Neuroimaging Abnormalities in Multiple Sclerosis, Major Depression and Chronic Fatigue Syndrome Myalgic Encephalomyelitis: is There a Common CauseReportar como inadecuado




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Molecular Neurobiology

pp 1–18

First Online: 17 May 2017Received: 16 March 2017Accepted: 03 May 2017DOI: 10.1007-s12035-017-0598-z

Cite this article as: Morris, G., Berk, M. & Puri, B.K. Mol Neurobiol 2017. doi:10.1007-s12035-017-0598-z

Abstract

There is copious evidence of abnormalities in resting-state functional network connectivity states, grey and white matter pathology and impaired cerebral perfusion in patients afforded a diagnosis of multiple sclerosis, major depression or chronic fatigue syndrome CFS myalgic encephalomyelitis. Systemic inflammation may well be a major element explaining such findings. Inter-patient and inter-illness variations in neuroimaging findings may arise at least in part from regional genetic, epigenetic and environmental variations in the functions of microglia and astrocytes. Regional differences in neuronal resistance to oxidative and inflammatory insults and in the performance of antioxidant defences in the central nervous system may also play a role. Importantly, replicated experimental findings suggest that the use of high-resolution SPECT imaging may have the capacity to differentiate patients afforded a diagnosis of CFS from those with a diagnosis of depression. Further research involving this form of neuroimaging appears warranted in an attempt to overcome the problem of aetiologically heterogeneous cohorts which probably explain conflicting findings produced by investigative teams active in this field. However, the ionising radiation and relative lack of sensitivity involved probably preclude its use as a routine diagnostic tool.

KeywordsChronic fatigue syndrome Depression Inflammation Multiple sclerosis Neuroimaging 



Autor: Gerwyn Morris - Michael Berk - Basant K. Puri

Fuente: https://link.springer.com/



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