Venous thromboembolism in hospitalized patients receiving chemotherapy for malignancies at Japanese community hospital: prospective observational studyReportar como inadecuado




Venous thromboembolism in hospitalized patients receiving chemotherapy for malignancies at Japanese community hospital: prospective observational study - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Cancer

, 17:351

Translational oncology

Abstract

BackgroundAlthough Asian population was recognized to have a lower risk of venous thromboembolism VTE, its increasing prevalence and incidence remain unclear in patients with malignancies. We attempted to predict VTE development using activation markers of coagulation and fibrinolysis.

MethodsWe enrolled patients with malignancy admitted to Tonan Hospital between April and December 2014 to receive a new-for-them chemotherapy regimen. All patients were examined for VTE by computed tomography and whole-leg compression ultrasonography before chemotherapy and three months later. We also examined plasma levels of thrombin-antithrombin complex TAT and plasmin α2-plasmin inhibitor complex PIC before chemotherapy. The cut off values of TAT and PIC were set at 2.1 ng-mL and 1.8 μg-mL, respectively.

ResultsOf 97 patients, the majority 67% had distant metastases. The most common malignancies were colorectal 26%, breast 23%, and stomach 19% cancer. VTE was detected in 29 patients 31%; all were asymptomatic. VTE was newly developed in 12 patients in the three-month observation period, which means the incidence was 49 per 1000 person-years. Non-increased PIC with increased TAT was the only significant risk factor for both VTE prevalence and incidence in multivariate analysis, and the odds ratios were 3.0 95% confidence interval, 1.1–8.2; P = 0.034 and 9.4 95% confidence interval, 1.7–51.9; P = 0.011, respectively.

ConclusionsThe prevalence and incidence of VTE were high in hospitalized Japanese patients receiving chemotherapy for malignancies. Non-increased PIC with increased levels of TAT may be an independent risk factor for VTE development.

KeywordsAntineoplastic agents Antithrombin III-protease complex Biomarkers Blood coagulation Fibrinolysis Patient admission Plasmin-plasmin inhibitor complex Prospective studies Risk factors Venous thromboembolism AbbreviationsCIConfidence interval

CTComputed tomography

DVTDeep vein thrombosis

F1 + 2Prothrombin fragment 1 + 2

OROdds ratio

PICPlasmin α2-plasmin inhibitor complex

TATThrombin-antithrombin complex

VTEVenous thromboembolism





Autor: Hiromitsu Kitayama - Tomohiro Kondo - Junko Sugiyama - Kazutomo Kurimoto - Yasuhiro Nishino - Michiaki Hirayama - Yasushi T

Fuente: https://link.springer.com/







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