Long acting β2-adrenocepter agonists are not associated with atrial arrhythmias after pulmonary resectionReportar como inadecuado




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Journal of Cardiothoracic Surgery

, 12:35

First Online: 19 May 2017Received: 11 July 2016Accepted: 12 May 2017DOI: 10.1186-s13019-017-0606-4

Cite this article as: Yamanashi, K., Marumo, S., Sumitomo, R. et al. J Cardiothorac Surg 2017 12: 35. doi:10.1186-s13019-017-0606-4

Abstract

BackgroundLong-acting β2-adrenoceptor agonists have been shown to increase the risk of atrial arrhythmias in patients with stable chronic obstructive pulmonary disease. The aim of this study was to investigate whether perioperative long-acting β2-adrenoceptor agonists treatment would increase the risk of postoperative atrial arrhythmias after lung cancer surgery in chronic obstructive pulmonary disease patients.

MethodsWe retrospectively analyzed 174 consecutive chronic obstructive pulmonary disease patients with non-small-cell lung cancer who underwent lobectomy or segmentectomy. The subjects were divided into those with or without perioperative long-acting β2-adrenoceptor agonists treatment. Postoperative cardiopulmonary complications were compared between the two groups.

ResultsThere were no statistically significant differences between the perioperative long-acting β2-adrenoceptor agonists treatment group and the control group in the incidence of postoperative atrial arrhythmias P = 0.629. In 134 propensity-score–matched pairs, including variables such as age, gender, comorbidities, smoking history, operation procedure, lung-cancer staging, and respiratory function, there were no significant differences between the two groups in the incidence of postoperative cardiopulmonary complications, including atrial arrhythmias.

ConclusionsPerioperative administration of long-acting β2-adrenoceptor agonists might not increase the incidence of postoperative atrial arrhythmias after surgical resection for non-small-cell lung cancer in chronic obstructive pulmonary disease patients.

KeywordsLung cancer surgery Long-acting β2-adrenoceptor agonists Postoperative respiratory complications AbbreviationsAFAtrial fibrillation

AMIAcute myocardial infarction

ARDSAcute respiratory distress syndrome

CHFCongestive heart failure

COPDChronic obstructive pulmonary disease

FEV1Forced expiratory volume in 1 s

FVCForced vital capacity

GOLDGlobal Initiative for Chronic Obstructive Lung Disease

NSCLCNon-small-cell lung cancer

PSVTParoxysmal supraventricular tachycardia

VATSVideo-assisted thoracoscopic surgery

VTventricular tachycardia

Electronic supplementary materialThe online version of this article doi:10.1186-s13019-017-0606-4 contains supplementary material, which is available to authorized users.





Autor: Keiji Yamanashi - Satoshi Marumo - Ryota Sumitomo - Tsuyoshi Shoji - Motonari Fukui - Toshiro Katayama - Cheng-long Huang

Fuente: https://link.springer.com/







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