High expression of cyclin D1 is associated to high proliferation rate and increased risk of mortality in women with ER-positive but not in ER-negative breast cancersReportar como inadecuado




High expression of cyclin D1 is associated to high proliferation rate and increased risk of mortality in women with ER-positive but not in ER-negative breast cancers - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Breast Cancer Research and Treatment

pp 1–12

First Online: 20 May 2017Received: 22 February 2017Accepted: 13 May 2017DOI: 10.1007-s10549-017-4294-5

Cite this article as: Ahlin, C., Lundgren, C., Embretsén-Varro, E. et al. Breast Cancer Res Treat 2017. doi:10.1007-s10549-017-4294-5

Abstract

PurposeCyclin D1 has a central role in cell cycle control and is an important component of estrogen regulation of cell cycle progression. We have previously shown that high cyclin D expression is related to aggressive features of ER-positive but not ER-negative breast cancer. The aims of the present study were to validate this differential ER-related effect and furthermore explore the relationship between cyclin D overexpression and CCND1 gene amplification status in a node-negative breast cancer case–control study.

MethodsImmunohistochemical nuclear expression of cyclin D1 n = 364 and amplification of the gene CCND1 by fluorescent in situ hybridization n = 255 was performed on tissue microarray sections from patients with T1-2N0M0 breast cancer. Patients given adjuvant chemotherapy were excluded. The primary event was defined as breast cancer death. Breast cancer-specific survival was analyzed in univariate and multivariable models using conditional logistic regression.

ResultsExpression of cyclin D1 above the median 61.7% in ER breast cancer was associated with an increased risk for breast cancer death OR 3.2 95% CI 1.5–6.8 also when adjusted for tumor size and grade OR 3.1. No significant prognostic impact of cyclin D1 expression was found among ER-negative cases. Cyclin D1 overexpression was significantly associated to high expression of the proliferation markers cyclins A ρ 0.19, p = 0.006 and B ρ 0.18, p = 0.003 in ER-positive tumors, but not in ER-negative cases. There was a significant association between CCND1 amplification and cyclin D1 expression p = 0.003, but CCND1 amplification was not statistically significantly prognostic HR 1.4, 95% CI 0.4–4.4.

ConclusionWe confirmed our previous observation that high cyclin D1 expression is associated to high proliferation and a threefold higher risk of death from breast cancer in ER-positive breast cancer.

KeywordsBreast cancer Proliferation Cyclin D1 CCND1 



Autor: Cecilia Ahlin - Claudia Lundgren - Elin Embretsén-Varro - Karin Jirström - Carl Blomqvist - M. -L. Fjällskog

Fuente: https://link.springer.com/



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