Fc-receptor mediates clearance of immune complex-like material in Crohns disease patients with elevated liver enzymesReportar como inadecuado




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Canadian Journal of Gastroenterology - Volume 1 1987, Issue 1, Pages 18-22

Clinical Gastroenterology Received 4 June 1987; Accepted 29 July 1987

Copyright © 1987 Hindawi Publishing Corporation. This open-access article is distributed under the terms of the Creative Commons Attribution Non-Commercial License CC BY-NC http:-creativecommons.org-licenses-by-nc-4.0-, which permits reuse, distribution and reproduction of the article, provided that the original work is properly cited and the reuse is restricted to noncommercial purposes.

Abstract

The reticuloendothelial system of patients with ulcerative colitisand associated liver disease is impaired in its ability to clear immune complex-likematerial from the systemic circulation. The purpose of the present study was todetermine whether patients with Crohn-s disease and associated liver enzyme abnormalities manifest the same reticuloendothelial system clearance defect. Autologousred cells were radiolabelled with

Cr and sensitized with anti-RhD immunoglobulinG in vitro. After intravenous infusion of the labelled antibody-coated red cells,the radioactivity content of timed blood specimens was measured. The time requiredby the reticuloendmhclial system to clear one-half the labelled cells from the circulation T1-2 was then determined. The T1-2 clearance times in nine Crohn-s diseasepatients with elevated scrum liver enzyme levels 59.7+6.4 mins, mean + SEM wassimilar to that of nine Crohn-s disease patients with normal liver enzyme levels50.7+4.6 mins, 12 chronic liver disease control patients 63.4+6.3 mins and 12healthy volunteers 49.1+3.1 mins P>0.05. The results of this study indicate thatthe reticuloendothelial system clearance defect described in patients with ulcerativecolitis and associated liver disease is not present in patients with Crohn-s disease andassociated mild liver enzyme abnormalities.





Autor: G.Y. Minuk, C. Bohme, N.B. Hershfield, W.Y. Lee, K.L. MacCannell, L.M. Price, E.A. Shaffer, and L.R. Sutherland

Fuente: https://www.hindawi.com/



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