Isolation of Bioactive Compounds That Relate to the Anti-Platelet Activity of Cymbopogon ambiguusReportar como inadecuado




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Evidence-Based Complementary and Alternative MedicineVolume 2010 2010, Article ID 467134, 8 pages

Original Article

Institute for Glycomics, Gold Coast campus, Griffith University, Queensland, 4222, Australia

Plate-forme d-imagerie dynamique, Institut Pasteur, Paris Cedex 15, France

Genomics Research Centre, Gold Coast campus, Griffith University, Queensland, 4222, Australia

Received 27 May 2009; Accepted 19 November 2009

Copyright © 2011 I. Darren Grice et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Infusions and decoctions of Cymbopogon ambiguus have been used traditionally in Australia for the treatment of headache, chest infections and muscle cramps. The aim of the present study was to screen and identify bioactive compounds from C. ambiguus that could explain this plant’s anti-headache activity. A dichloromethane extract of C. ambiguus was identified as having activity in adenosine-diphosphate-induced human platelet aggregation and serotonin-release inhibition bioassays. Subsequent fractionation of this extract led to the isolation of four phenylpropenoids, eugenol, elemicin, eugenol methylether and trans-isoelemicin. While both eugenol and elemicin exhibited dose-dependent inhibition of ADP-induced human platelet serotonin release, only eugenol displayed potent inhibitory activity with an IC50 value of 46.6 μM, in comparison to aspirin, with an IC50 value of 46.1 μM. These findings provide evidence to support the therapeutic efficacy of C. ambiguus in the non-conventional treatment of headache and inflammatory conditions.





Autor: I. Darren Grice, Kelly L. Rogers, and Lyn R. Griffiths

Fuente: https://www.hindawi.com/



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