Suppression of Inflammation and Arthritis by Orally Administrated Cardiotoxin from Naja naja atraReport as inadecuate

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Evidence-Based Complementary and Alternative Medicine - Volume 2015 2015, Article ID 387094, 12 pages -

Research ArticleDepartment of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, Soochow University School of Pharmaceutical Science, 199 Ren Ai Road, Suzhou 215123, China

Received 11 October 2014; Revised 17 December 2014; Accepted 18 December 2014

Academic Editor: Ke Ren

Copyright © 2015 Cao-Xin Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cardiotoxin CTX from Naja naja atra venom NNAV reportedly had analgesic effect in animal models but its role in inflammation and arthritis was unknown. In this study, we investigated the analgesic, anti-inflammatory, and antiarthritic actions of orally administered CTX-IV isolated from NNAV on rodent models of inflammation and adjuvant arthritis. CTX had significant anti-inflammatory effects in models of egg white induced nonspecific inflammation, filter paper induced rat granuloma formation, and capillary osmosis tests. CTX significantly reduced the swelling of paw induced by egg white, the inflammatory exudation, and the formation of granulomas. CTX reduced the swelling of paw, the AA clinical scores, and pathological alterations of joint. CTX significantly decreased the number of the CD4 T cells and inhibited the expression of relevant proinflammatory cytokines IL-17 and IL-6. CTX significantly inhibited the secretion of proinflammatory cytokine IL-6 and reduced the level of p-STAT3 in FLS. These results suggest that CTX inhibits inflammation and inflammatory pain and adjuvant-induced arthritis. CTX may be a novel therapeutic drug for treatment of arthritis.

Author: Cao-Xin Chen, Jie-Yu Chen, Jian-Qun Kou, Yin-Li Xu, Shu-Zhi Wang, Qi Zhu, Lu Yang, and Zheng-Hong Qin



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