Assessment of Technetium-99m Labeled Macroaggregated Albumin Rhinoscintigraphy for the Measurement of Nasal Mucociliary Transport Rate: Intratest, Interobserver, and Intraobserver ReproducibilityReportar como inadecuado




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ScientificaVolume 2014 2014, Article ID 982515, 5 pages

Clinical Study

Department of Nuclear Medicine, Faculty of Medicine, Dicle University, 21280 Diyarbakir, Turkey

Department of Nuclear Medicine, Faculty of Medicine, Harran University, 63300 Sanliurfa, Turkey

Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Dicle University, 21280 Diyarbakir, Turkey

Received 7 January 2014; Accepted 2 February 2014; Published 5 March 2014

Academic Editors: A. Orlova, O. Prante, and W. Wadsak

Copyright © 2014 Zeki Dostbil et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. The measurement of mucociliary transport velocity by rhinoscintigraphy with Tc-99m-macroaggregated albumin

Tc-MAA is reliable measure of mucociliary clearance. The aim of this study is to assess the intratest, interobserver, and intraobserver reproducibility of nasal mucociliary transport rate NMTR measurement. Materials and Methods. Twenty-two subjects were evaluated to determine intratest reproducibility and a group of 35 subjects was examined to determine inter- and intraobserver reproducibility. Rhinoscintigraphy with

Tc-MAA was used to measure NMTR in all study subjects. Paired NMTR measurements were compared using a range of statistical methodologies. Intraclass correlation coefficients ICC and repeatability coefficients and Bland-Altman plots were applied to assess the degree of intratest, interobserver, and intraobserver variation. Results. Statistical analysis of test and retest experiments demonstrated the statistical equivalence of intratest NMTR measurements, interobserver NMTR measurements, and intraobserver NMTR measurements. The intratest ICC, interobserver ICC, and intraobserver ICC were 0.96, 0.83, and 0.91, respectively, indicating that intratest and intraobserver reproducibility are excellent and interobserver reproducibility is good. Conclusions. Rhinoscintigraphy using

Tc-MAA results in highly reproducible measurement of NMTR. The use of radionuclide imaging in measuring NMTR results in excellent intratest and intraobserver reproducibility and good interobserver reliability.





Autor: Zeki Dostbil, Yusuf Dag, Ozlem Cetinkaya, Mehmet Akdag, and Bekir Tasdemir

Fuente: https://www.hindawi.com/



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