Maternal blood cadmium, lead and arsenic levels, nutrient combinations, and offspring birthweight.Reportar como inadecuado

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Journal Title:

BMC Public Health


Volume 17, Number 1


BioMed Central | 2017-04-24, Pages 354-354

Type of Work:

Article | Final Publisher PDF

Abstract: BACKGROUND: Cadmium Cd, lead Pb and arsenic As are common environmental contaminants that have been associated with lower birthweight. Although some essential metals may mitigate exposure, data are inconsistent. This study sought to evaluate the relationship between toxic metals, nutrient combinations and birthweight among 275 mother-child pairs. METHODS: Non-essential metals, Cd, Pb, As, and essential metals, iron Fe, zinc Zn, selenium Se, copper Cu, calcium Ca, magnesium Mg, and manganese Mn were measured in maternal whole blood obtained during the first trimester using inductively coupled plasma mass spectrometry. Folate concentrations were measured by microbial assay. Birthweight was obtained from medical records. We used quantile regression to evaluate the association between toxic metals and nutrients due to their underlying wedge-shaped relationship. Ordinary linear regression was used to evaluate associations between birth weight and toxic metals. RESULTS: After multivariate adjustment, the negative association between Pb or Cd and a combination of Fe, Se, Ca and folate was robust, persistent and dose-dependent p < 0.05. However, a combination of Zn, Cu, Mn and Mg was positively associated with Pb and Cd levels. While prenatal blood Cd and Pb were also associated with lower birthweight. Fe, Se, Ca and folate did not modify these associations. CONCLUSION: Small sample size and cross-sectional design notwithstanding, the robust and persistent negative associations between some, but not all, nutrient combinations with these ubiquitous environmental contaminants suggest that only some recommended nutrient combinations may mitigate toxic metal exposure in chronically exposed populations. Larger longitudinal studies are required to confirm these findings.

Subjects: Health Sciences, Epidemiology - Biology, Bioinformatics - Research Funding: This work was supported in part by the generous donation from Howard and Julia Clark, and research grants from the National Institute of Health Grant no. R01-ES016772, P30 ES025128 and National Cancer Institute R25CA057726.

Keywords: Birthweight - Dietary nutrients - Epidemiology - Toxic metals -

Autor: Yiwen Luo, Lauren McCullough, Jung-Ying Tzeng, Thomas Darrah, Avner Vengosh, Rachel L. Maguire, Arnab Maity, Carmen Samuel-Hodge,



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