Influence of coronary artery stenosis severity and coronary collateralization on extent of chronic myocardial scar: insights from quantitative coronary angiography and delayed-enhancement MRI.Reportar como inadecuado




Influence of coronary artery stenosis severity and coronary collateralization on extent of chronic myocardial scar: insights from quantitative coronary angiography and delayed-enhancement MRI. - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Journal Title:

Open Cardiovascular Medicine Journal

Volume:

Volume 2, Number 1

Publisher:

Bentham Open | 2008, Pages 79-86

Type of Work:

Article | Final Publisher PDF

Abstract: OBJECTIVES: In patients with chronic ischemic heart disease, the relationship between coronary artery lesion severity and myocardial scarring is unknown.The purpose of this study was to examine the relationship between proximal coronary artery stenosis severity, the amount of coronary collateralization, and myocardial scar extent in the distal distribution of the affected coronary artery based on both quantitative coronary angiography QCA and delayed-enhancement magnetic resonance imaging DE-MRI. METHODS: Thirty-four patients 26 males, 8 females; age range: 35-86 years with a coronary artery containing a single, proximal stenosis >-=30% by quantitative coronary angiography QCA underwent DE-MRI. The relationship between stenosis severity, collateralization, and myocardial scar morphology area, transmurality and patchiness was examined using linear mixed-model ANCOVA. RESULTS: There was a statistically significant correlation between stenosis severity and scar extent r=0.53, p<0.01. Patients with hemodynamically significant stenoses >-=70% exhibited significantly greater collateralization p<0.05 and scar extent p<0.01 than patients with <70% stenosis. However, scarring was often found in patients with stenoses <70%. Also, greater stenosis severity 93+-14% and mean scar extent 41+-35% were found in patients with collaterals than in patients without collaterals diameter stenosis 48+-10%, p<0.01 scar extent 19+-29%, p=0.01. CONCLUSIONS: Using QCA and DE-MRI, we demonstrate a significant relationship between coronary artery stenosis severity and myocardial scar extent, in the absence of a documented history of acute infarction. The relationship likely reflects increasing ischemia leading to scar formation in the range of angiographically significant stenosis. However, in the absence of collateralization, scar was observed without significant stenosis, especially in females.

Subjects: Health Sciences, Radiology - Health Sciences, General - Keywords: Coronary collateralization - coronary stenosis - magnetic resonance imaging - myocardial ischemia - myocardial scar - quantitative coronary angiography. -



Autor: Daniel Bexell Daniel Bexell, Randolph M Setser, Paul Schoenhagen, Michael L Lieber, Sorin J Brener, Thomas B Ivanc, Eva M Balazs,

Fuente: https://open.library.emory.edu/



DESCARGAR PDF




Documentos relacionados